Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/145600
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dc.contributor.authorTaye, Biruhalemen_US
dc.contributor.authorChen, Huien_US
dc.contributor.authorYeo, Dawn Su-Yinen_US
dc.contributor.authorSeah, Shirley Gek-Khengen_US
dc.contributor.authorWong, Michelle Su-Yenen_US
dc.contributor.authorSugrue, Richard J.en_US
dc.contributor.authorTan, Boon Huanen_US
dc.date.accessioned2020-12-30T02:23:59Z-
dc.date.available2020-12-30T02:23:59Z-
dc.date.issued2020-
dc.identifier.citationTaye, B., Chen, H., Yeo, D. S.-Y., Seah, S. G.-K., Wong, M. S.-Y., Sugrue, R. J., & Tan, B. H. (2020). A system based-approach to examine host response during infection with influenza a virus subtype H7N9 in human and avian cells. Cells, 9(2), 448-. doi:10.3390/cells9020448en_US
dc.identifier.issn2073-4409en_US
dc.identifier.urihttps://hdl.handle.net/10356/145600-
dc.description.abstractAlthough the influenza A virus H7N9 subtype circulates within several avian species, it can also infect humans with a severe disease outcome. To better understand the biology of the H7N9 virus we examined the host response to infection in avian and human cells. In this study we used the A/Anhui/1/2013 strain, which was isolated during the first wave of the H7N9 epidemic. The H7N9 virus-infected both human (Airway Epithelial cells) and avian (Chick Embryo Fibroblast) cells, and each infected host transcriptome was examined with bioinformatic tools and compared with other representative avian and human influenza A virus subtypes. The H7N9 virus induced higher expression changes (differentially regulated genes) in both cell lines, with more prominent changes observed in avian cells. Ortholog mapping of differentially expression genes identified significant enriched common and cell-type pathways during H7N9 infections. This data confirmed our previous findings that different influenza A virus subtypes have virus-specific replication characteristics and anti-virus signaling in human and avian cells. In addition, we reported for the first time, the new HIPPO signaling pathway in avian cells, which we hypothesized to play a vital role to maintain the antiviral state of H7N9 virus-infected avian cells. This could explain the absence of disease symptoms in avian species that tested positive for the presence of H7N9 virus.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relation.ispartofCellsen_US
dc.rights© 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectScience::Biological sciencesen_US
dc.subjectScience::Medicineen_US
dc.titleA system based-approach to examine host response during infection with influenza a virus subtype H7N9 in human and avian cellsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.organizationInfection and Immunityen_US
dc.identifier.doi10.3390/cells9020448-
dc.description.versionPublished versionen_US
dc.identifier.pmid32075271-
dc.identifier.issue2en_US
dc.identifier.volume9en_US
dc.subject.keywordsInfluenza A Virusen_US
dc.subject.keywordsH7N9en_US
dc.description.acknowledgementWe thank the Ministry of Education, and DSO National Laboratories for funding this study. B.T. was awarded by the Singapore International Graduate Award (SINGA) scholarship (A*STAR, Singapore) and CH (MOE scholarship).en_US
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