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dc.contributor.authorLoh, Jia Tongen_US
dc.contributor.authorTeo, Joey Kay Huien_US
dc.contributor.authorLim, Hong-Hwaen_US
dc.contributor.authorLam, Kong-Pengen_US
dc.identifier.citationLoh, J. T., Teo, J. K. H., Lim, H.-H., & Lam, K.-P. (2020). Emerging roles of downstream of kinase 3 in cell signaling. Frontiers in Immunology, 11, 566192-. doi:10.3389/fimmu.2020.566192en_US
dc.description.abstractDownstream of kinase (Dok) 3 is a member of the Dok family of adaptor proteins known to regulate signaling pathways downstream of various immunoreceptors. As Dok-3 lacks intrinsic catalytic activity, it functions primarily as a molecular scaffold to facilitate the nucleation of protein complexes in a regulated manner and hence, achieve specificity in directing signaling cascades. Since its discovery, considerable progress has been made toward defining the role of Dok-3 in limiting B cell-receptor signaling. Nonetheless, Dok-3 has since been implicated in the signaling of Toll-like and C-type lectin receptors. Emerging data further demonstrate that Dok-3 can act both as an activator and inhibitor, in lymphoid and non-lymphoid cell types, suggesting Dok-3 involvement in a plethora of signal transduction pathways. In this review, we will focus on the structure and expression profile of Dok-3 and highlight its role during signal transduction in B cells, innate cells as well as in bone and lung tissues.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Health (MOH)en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.relation.ispartofFrontiers in Immunologyen_US
dc.rights© 2020 Loh, Teo, Lim and Lam. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleEmerging roles of downstream of kinase 3 in cell signalingen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.organizationBioprocessing Technology Institute, A*STARen_US
dc.contributor.organizationSingapore Immunology Network, A*STARen_US
dc.description.versionPublished versionen_US
dc.description.acknowledgementThis work is supported by the Singapore Ministry of Health’s National Medical Research Council under its Open Fund–Young Individual Research Grant (NMRC/OFYIRG/083/2018 to JTL) and Open Fund-Individual Research Grant (NMRC/OFIRG19may-0083 to K-PL, JTL, and H-HL), and an A∗STAR core grant (to K-PL).en_US
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