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Title: Choroidal neovascularization : mechanisms of endothelial dysfunction
Authors: Yeo, Natalie Jia Ying
Chan, Ebenezer Jia Jun
Cheung, Christine
Keywords: Science::Medicine
Issue Date: 2019
Source: Yeo, N. J. Y. , Chan, E. J. J., & Cheung, C. (2019). Choroidal neovascularization : mechanisms of endothelial dysfunction. Frontiers in Pharmacology, 10, 1363-. doi:10.3389/fphar.2019.01363
Project: MOE2018-T2-1-042
Journal: Frontiers in Pharmacology
Abstract: Many conditions affecting the heart, brain, and even the eyes have their origins in blood vessel pathology, underscoring the role of vascular regulation. In age-related macular degeneration (AMD), there is excessive growth of abnormal blood vessels in the eye (choroidal neovascularization), eventually leading to vision loss due to detachment of retinal pigmented epithelium. As the advanced stage of this disease involves loss of retinal pigmented epithelium, much less attention has been given to early vascular events such as endothelial dysfunction. Although current gold standard therapy using inhibitors of vascular endothelial growth factor (VEGF) have achieved initial successes, some drawbacks include the lack of long-term restoration of visual acuity, as well as a subset of the patients being refractory to existing treatment, alluding us and others to hypothesize upon VEGF-independent mechanisms. Against this backdrop, we present here a nonexhaustive review on the vascular underpinnings of AMD, implications with genetic and systemic factors, experimental models for studying choroidal neovascularization, and interestingly, on both endothelial-centric pathways and noncell autonomous mechanisms. We hope to shed light on future research directions in improving vascular function in ocular disorders.
ISSN: 1663-9812
DOI: 10.3389/fphar.2019.01363
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
School of Social Sciences 
Organisations: Institute of Molecular and Cell Biology, A*STAR
Rights: © 2019 Yeo, Chan and Cheung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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