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dc.contributor.authorFoo, Aaron Song Chuanen_US
dc.contributor.authorSoong, Tuck Wahen_US
dc.contributor.authorYeo, Tseng Tsaien_US
dc.contributor.authorLim, Kah-Leongen_US
dc.identifier.citationFoo, A. S. C., Soong, T. W., Yeo, T. T., & Lim, K.-L. (2020). Mitochondrial dysfunction and Parkinson’s disease — near-infrared photobiomodulation as a potential therapeutic strategy. Frontiers in Aging Neuroscience, 12, 89-. doi:10.3389/fnagi.2020.00089en_US
dc.description.abstractAs the main driver of energy production in eukaryotes, mitochondria are invariably implicated in disorders of cellular bioenergetics. Given that dopaminergic neurons affected in Parkinson’s disease (PD) are particularly susceptible to energy fluctuations by their high basal energy demand, it is not surprising to note that mitochondrial dysfunction has emerged as a compelling candidate underlying PD. A recent approach towards forestalling dopaminergic neurodegeneration in PD involves near-infrared (NIR) photobiomodulation (PBM), which is thought to enhance mitochondrial function of stimulated cells through augmenting the activity of cytochrome C oxidase. Notwithstanding this, our understanding of the neuroprotective mechanism of PBM remains far from complete. For example, studies focusing on the effects of PBM on gene transcription are limited, and the mechanism through which PBM exerts its effects on distant sites (i.e., its “abscopal effect”) remains unclear. Also, the clinical application of NIR in PD proves to be challenging. Efficacious delivery of NIR light to the substantia nigra pars compacta (SNpc), the primary site of disease pathology in PD, is fraught with technical challenges. Concerted efforts focused on understanding the biological effects of PBM and improving the efficiency of intracranial NIR delivery are therefore essential for its successful clinical translation. Nonetheless, PBM represents a potential novel therapy for PD. In this review, we provide an update on the role of mitochondrial dysfunction in PD and how PBM may help mitigate the neurodegenerative process. We also discussed clinical translation aspects of this treatment modality using intracranially implanted NIR delivery devices.en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.relation.ispartofFrontiers in Aging Neuroscienceen_US
dc.rights© 2020 Foo, Soong, Yeo and Lim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.titleMitochondrial dysfunction and Parkinson’s disease — near-infrared photobiomodulation as a potential therapeutic strategyen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.description.versionPublished versionen_US
dc.subject.keywordsParkinson’s Diseaseen_US
dc.subject.keywordsMitochondria Dysfunctionen_US
dc.description.acknowledgementThis work was supported by grants from the National Medical Research Council—Translational Clinical Research Program in Parkinson’s disease (K-LL) and Lee Kong Chian School of Medicine (K-LL). Dr. AF is supported by the Department of Surgery, National University Hospital and a graduate scholarship from the National University of Singapore Research Scholars Programme.en_US
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