Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/145721
Title: Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria
Authors: Bhattacharjya, Surajit
Straus, Suzana K.
Keywords: Science::Biological sciences
Issue Date: 2020
Source: Bhattacharjya, S., & Straus, S. K. (2020). Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria. International Journal of Molecular Sciences, 21(16), 5773-. doi:10.3390/ijms21165773
Journal: International Journal of Molecular Sciences
Abstract: In an era where the pipeline of new antibiotic development is drying up, the continuous rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine threats to human health. Although antimicrobial peptides (AMPs) may serve as promising leads against drug resistant bacteria, only a few AMPs are in advanced clinical trials. The limitations of AMPs, namely their low in vivo activity, toxicity, and poor bioavailability, need to be addressed. Here, we review engineering of frog derived short α-helical AMPs (aurein, temporins) and lipopolysaccharide (LPS) binding designed β-boomerang AMPs for further development. The discovery of novel cell selective AMPs from the human proprotein convertase furin is also discussed.
URI: https://hdl.handle.net/10356/145721
ISSN: 1661-6596
DOI: 10.3390/ijms21165773
Schools: School of Biological Sciences 
Rights: © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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