Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/145721
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dc.contributor.authorBhattacharjya, Surajiten_US
dc.contributor.authorStraus, Suzana K.en_US
dc.date.accessioned2021-01-06T02:13:32Z-
dc.date.available2021-01-06T02:13:32Z-
dc.date.issued2020-
dc.identifier.citationBhattacharjya, S., & Straus, S. K. (2020). Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria. International Journal of Molecular Sciences, 21(16), 5773-. doi:10.3390/ijms21165773en_US
dc.identifier.issn1661-6596en_US
dc.identifier.urihttps://hdl.handle.net/10356/145721-
dc.description.abstractIn an era where the pipeline of new antibiotic development is drying up, the continuous rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine threats to human health. Although antimicrobial peptides (AMPs) may serve as promising leads against drug resistant bacteria, only a few AMPs are in advanced clinical trials. The limitations of AMPs, namely their low in vivo activity, toxicity, and poor bioavailability, need to be addressed. Here, we review engineering of frog derived short α-helical AMPs (aurein, temporins) and lipopolysaccharide (LPS) binding designed β-boomerang AMPs for further development. The discovery of novel cell selective AMPs from the human proprotein convertase furin is also discussed.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.rights© 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectScience::Biological sciencesen_US
dc.titleDesign, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteriaen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doi10.3390/ijms21165773-
dc.description.versionPublished versionen_US
dc.identifier.pmid32796755-
dc.identifier.issue16en_US
dc.identifier.volume21en_US
dc.subject.keywordsMulti-drug Resistant Bacteriaen_US
dc.subject.keywordsExtensively Drug Resistant Bacteriaen_US
dc.description.acknowledgementS.B. acknowledges funding from Biomedical Research Council (BMRC), Singapore and Ministry of Education (MOE), Singapore. S.K.S. thanks the Natural Sciences and Engineering Research Council of Canada for funding.en_US
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