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Title: Role of exosomes in cancer-related cognitive impairment
Authors: Koh, Yong Qin
Tan, Chia Jie
Toh, Yi Long
Sze, Siu Kwan
Ho, Han Kiat
Limoli, Charles L.
Chan, Alexandre
Keywords: Science::Biological sciences
Issue Date: 2020
Source: Koh, Y. Q., Tan, C. J., Toh, Y. L., Sze, S. K., Ho, H. K., Limoli, C. L., & Chan, A. (2020). Role of exosomes in cancer-related cognitive impairment. International Journal of Molecular Sciences, 21(8), 2755-. doi:10.3390/ijms21082755
Journal: International Journal of Molecular Sciences
Abstract: A decline in cognitive function following cancer treatment is one of the most commonly reported post-treatment symptoms among patients with cancer and those in remission, and include memory, processing speed, and executive function. A clear understanding of cognitive impairment as a result of cancer and its therapy can be obtained by delineating structural and functional changes using brain imaging studies and neurocognitive assessments. There is also a need to determine the underlying mechanisms and pathways that impact the brain and affect cognitive functioning in cancer survivors. Exosomes are small cell-derived vesicles formed by the inward budding of multivesicular bodies, and are released into the extracellular environment via an exocytic pathway. Growing evidence suggests that exosomes contribute to various physiological and pathological conditions, including neurological processes such as synaptic plasticity, neuronal stress response, cell-to-cell communication, and neurogenesis. In this review, we summarize the relationship between exosomes and cancer-related cognitive impairment. Unraveling exosomes’ actions and effects on the microenvironment of the brain, which impacts cognitive functioning, is critical for the development of exosome-based therapeutics for cancer-related cognitive impairment.
ISSN: 1661-6596
DOI: 10.3390/ijms21082755
Rights: © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
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