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dc.contributor.authorToong, Daniel Wee Yeeen_US
dc.contributor.authorToh, Han Weien_US
dc.contributor.authorNg, Jaryl Chen Koonen_US
dc.contributor.authorWong, Philip En Houen_US
dc.contributor.authorLeo, Hwa Liangen_US
dc.contributor.authorVenkatraman, Subramanianen_US
dc.contributor.authorTan, Lay Pohen_US
dc.contributor.authorAng, Hui Yingen_US
dc.contributor.authorHuang, Yingyingen_US
dc.identifier.citationToong, D. W. Y., Toh, H. W., Ng, J. C. K., Wong, P. E. H., Leo, H. L., Venkatraman, S., . . . Huang, Y. (2020). Bioresorbable polymeric scaffold in cardiovascular applications. International Journal of Molecular Sciences, 21(10), 3444-. doi:10.3390/ijms21103444en_US
dc.description.abstractAdvances in material science and innovative medical technologies have allowed the development of less invasive interventional procedures for deploying implant devices, including scaffolds for cardiac tissue engineering. Biodegradable materials (e.g., resorbable polymers) are employed in devices that are only needed for a transient period. In the case of coronary stents, the device is only required for 6–8 months before positive remodelling takes place. Hence, biodegradable polymeric stents have been considered to promote this positive remodelling and eliminate the issue of permanent caging of the vessel. In tissue engineering, the role of the scaffold is to support favourable cell-scaffold interaction to stimulate formation of functional tissue. The ideal outcome is for the cells to produce their own extracellular matrix over time and eventually replace the implanted scaffold or tissue engineered construct. Synthetic biodegradable polymers are the favoured candidates as scaffolds, because their degradation rates can be manipulated over a broad time scale, and they may be functionalised easily. This review presents an overview of coronary heart disease, the limitations of current interventions and how biomaterials can be used to potentially circumvent these shortcomings in bioresorbable stents, vascular grafts and cardiac patches. The material specifications, type of polymers used, current progress and future challenges for each application will be discussed in this manuscript.en_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.rights© 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
dc.subjectScience::Biological sciencesen_US
dc.titleBioresorbable polymeric scaffold in cardiovascular applicationsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsBioresorbable Scaffoldsen_US
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