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Title: Bioresorbable polymeric scaffold in cardiovascular applications
Authors: Toong, Daniel Wee Yee
Toh, Han Wei
Ng, Jaryl Chen Koon
Wong, Philip En Hou
Leo, Hwa Liang
Venkatraman, Subramanian
Tan, Lay Poh
Ang, Hui Ying
Huang, Yingying
Keywords: Science::Biological sciences
Issue Date: 2020
Source: Toong, D. W. Y., Toh, H. W., Ng, J. C. K., Wong, P. E. H., Leo, H. L., Venkatraman, S., . . . Huang, Y. (2020). Bioresorbable polymeric scaffold in cardiovascular applications. International Journal of Molecular Sciences, 21(10), 3444-. doi:10.3390/ijms21103444
Journal: International Journal of Molecular Sciences
Abstract: Advances in material science and innovative medical technologies have allowed the development of less invasive interventional procedures for deploying implant devices, including scaffolds for cardiac tissue engineering. Biodegradable materials (e.g., resorbable polymers) are employed in devices that are only needed for a transient period. In the case of coronary stents, the device is only required for 6–8 months before positive remodelling takes place. Hence, biodegradable polymeric stents have been considered to promote this positive remodelling and eliminate the issue of permanent caging of the vessel. In tissue engineering, the role of the scaffold is to support favourable cell-scaffold interaction to stimulate formation of functional tissue. The ideal outcome is for the cells to produce their own extracellular matrix over time and eventually replace the implanted scaffold or tissue engineered construct. Synthetic biodegradable polymers are the favoured candidates as scaffolds, because their degradation rates can be manipulated over a broad time scale, and they may be functionalised easily. This review presents an overview of coronary heart disease, the limitations of current interventions and how biomaterials can be used to potentially circumvent these shortcomings in bioresorbable stents, vascular grafts and cardiac patches. The material specifications, type of polymers used, current progress and future challenges for each application will be discussed in this manuscript.
ISSN: 1661-6596
DOI: 10.3390/ijms21103444
Rights: © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
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