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Title: Association between serum vitamin D metabolites and metabolic function in healthy Asian adults
Authors: Ding, Cherlyn
Chan, Zhiling
Chooi, Yu Chung
Choo, John
Sadananthan, Suresh Anand
Michael, Navin
Velan, Sambasivam Sendhil
Leow, Melvin Khee-Shing
Magkos, Faidon
Keywords: Science::Medicine
Issue Date: 2020
Source: Ding, C., Chan, Z., Chooi, Y. C., Choo, J., Sadananthan, S. A., Michael, N., . . . Magkos, F. (2020). Association between serum vitamin D metabolites and metabolic function in healthy Asian adults. Nutrients, 12(12), 3706-. doi:10.3390/nu12123706
Project: BMSI/16-07803C-R20H
Journal: Nutrients
Abstract: The association between low vitamin D status and the development of type 2 diabetes mellitus is well established; however, intervention trials that increased serum vitamin D (through ultraviolet B exposure or dietary supplementation) provide mixed outcomes. Recent evidence suggests that metabolites directly related to vitamin D receptor activation—1α,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3—may be better markers of vitamin D repletion status. We tested the hypothesis that a vitamin D metabolite (VDM) index, calculated as the sum of normalized fasting serum concentrations of 1α,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3, is associated with metabolic function. We measured subcutaneous and visceral adipose tissue volume, intrahepatic triglyceride content, maximum oxygen uptake, insulin sensitivity (4 h hyperinsulinemic-euglycemic clamp), and insulin secretion (3 h meal tolerance test with mathematical modeling) and calculated the VDM index in 65 healthy Asian adults. Subjects with a low VDM index had lower peripheral insulin sensitivity and beta-cell function compared to subjects with a high VDM index (both p < 0.05), matched for age, sex, BMI, and serum 25-hydroxyvitamin D3. Serum 25-hydroxyvitamin D3 was not associated with peripheral insulin sensitivity or beta-cell function. Our results suggest that, rather than enhancing vitamin D substrate availability, upregulation of vitamin D action is more likely to lead to improvements in glucose homeostasis.
ISSN: 2072-6643
DOI: 10.3390/nu12123706
Rights: © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
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