Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/145995
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dc.contributor.authorMarselli, Lorellaen_US
dc.contributor.authorPiron, Anthonyen_US
dc.contributor.authorSuleiman, Maraen_US
dc.contributor.authorColli, Maikel L.en_US
dc.contributor.authorYi, Xiaoyanen_US
dc.contributor.authorKhamis, Amnaen_US
dc.contributor.authorCarrat, Gaelle R.en_US
dc.contributor.authorRutter, Guy A.en_US
dc.contributor.authorBugliani, Marcoen_US
dc.contributor.authorGiusti, Lauraen_US
dc.contributor.authorRonci, Maurizioen_US
dc.contributor.authorIbberson, Marken_US
dc.contributor.authorTuratsinze, Jean-Valeryen_US
dc.contributor.authorBoggi, Ugoen_US
dc.contributor.authorde Simone, Paoloen_US
dc.contributor.authorde Tata, Vincenzoen_US
dc.contributor.authorLopes, Miguelen_US
dc.contributor.authorNasteska, Danielaen_US
dc.contributor.authorde Luca, Carmelaen_US
dc.contributor.authorTesi, Martaen_US
dc.contributor.authorBosi, Emanueleen_US
dc.contributor.authorSingh, Pratibhaen_US
dc.contributor.authorCampani, Danielaen_US
dc.contributor.authorSchulte, Anke M.en_US
dc.contributor.authorSolimena, Micheleen_US
dc.contributor.authorHecht, Peteren_US
dc.contributor.authorRady, Brianen_US
dc.contributor.authorBakaj, Ivonaen_US
dc.contributor.authorPocai, Alessandroen_US
dc.contributor.authorNorquay, Lisaen_US
dc.contributor.authorThorens, Bernarden_US
dc.contributor.authorCanouil, Mickaëlen_US
dc.contributor.authorFroguel, Philippeen_US
dc.contributor.authorEizirik, Decio L.en_US
dc.contributor.authorCnop, Miriamen_US
dc.contributor.authorMarchetti, Pieroen_US
dc.date.accessioned2021-01-20T02:10:07Z-
dc.date.available2021-01-20T02:10:07Z-
dc.date.issued2020-
dc.identifier.citationMarselli, L., Piron, A., Suleiman, M., Colli, M. L., Yi, X., Khamis, A., . . . Marchetti, P. (2020). Persistent or transient human β cell dysfunction induced by metabolic stress : specific signatures and shared gene expression with type 2 diabetes. Cell Reports, 33(9), 108466-. doi:10.1016/j.celrep.2020.108466en_US
dc.identifier.issn2211-1247en_US
dc.identifier.other0000-0003-1189-3441-
dc.identifier.other0000-0002-0797-6087-
dc.identifier.other0000-0002-7505-5896-
dc.identifier.other0000-0001-6713-6170-
dc.identifier.other0000-0001-5987-734X-
dc.identifier.other0000-0003-1450-9521-
dc.identifier.other0000-0003-1527-1375-
dc.identifier.other0000-0002-5112-1692-
dc.identifier.urihttps://hdl.handle.net/10356/145995-
dc.description.abstractPancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate the molecular pathways underlying persistent or transient damage, and explore the relationships with T2D islet traits. Twenty-six islet preparations are exposed to several lipotoxic/glucotoxic conditions, some of which impair insulin release, depending on stressor type, concentration, and combination. The reversal of dysfunction occurs after washout for some, although not all, of the lipoglucotoxic insults. Islet transcriptomes assessed by RNA sequencing and expression quantitative trait loci (eQTL) analysis identify specific pathways underlying β cell failure and recovery. Comparison of a large number of human T2D islet transcriptomes with those of persistent or reversible β cell lipoglucotoxicity show shared gene expression signatures. The identification of mechanisms associated with human β cell dysfunction and recovery and their overlap with T2D islet traits provide insights into T2D pathogenesis, fostering the development of improved β cell-targeted therapeutic strategies.en_US
dc.language.isoenen_US
dc.relation.ispartofCell Reportsen_US
dc.rights© 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.subjectScience::Medicineen_US
dc.titlePersistent or transient human β cell dysfunction induced by metabolic stress : specific signatures and shared gene expression with type 2 diabetesen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1016/j.celrep.2020.108466-
dc.description.versionPublished versionen_US
dc.identifier.pmid33264613-
dc.identifier.scopus2-s2.0-85097044240-
dc.identifier.issue9en_US
dc.identifier.volume33en_US
dc.subject.keywordsType 2 Diabetesen_US
dc.subject.keywordsLipoglucotoxicityen_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:LKCMedicine Journal Articles
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