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dc.contributor.authorPattabiraman, Sundararaghavanen_US
dc.contributor.authorAzad, Gajendra Kumaren_US
dc.contributor.authorAmen, Trianaen_US
dc.contributor.authorBrielle, Shlomien_US
dc.contributor.authorPark, Jung Eunen_US
dc.contributor.authorSze, Siu Kwanen_US
dc.contributor.authorMeshorer, Eranen_US
dc.contributor.authorKaganovich, Danielen_US
dc.identifier.citationPattabiraman, S., Azad, G. K., Amen, T., Brielle, S., Park, J. E., Sze, S. K., … Kaganovich, D. (2020). Vimentin protects differentiating stem cells from stress. Scientific Reports, 10, 19525-. doi:10.1038/s41598-020-76076-4en_US
dc.description.abstractVimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian cells during embryogenesis, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in cell stiffness, cell motility, and cytoplasmic organization, yet it is widely considered to be dispensable for cellular function and organismal development. Here, we show that Vimentin plays a role in cellular stress response in differentiating cells, by recruiting aggregates, stress granules, and RNA-binding proteins, directing their elimination and asymmetric partitioning. In the absence of Vimentin, pluripotent embryonic stem cells fail to differentiate properly, with a pronounced deficiency in neuronal differentiation. Our results uncover a novel function for Vimentin, with important implications for development, tissue homeostasis, and in particular, stress response.en_US
dc.relation.ispartofScientific Reportsen_US
dc.rights© 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons .org/licenses/by/4.0/.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleVimentin protects differentiating stem cells from stressen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsIntermediate Filamentsen_US
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