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Title: Vimentin protects differentiating stem cells from stress
Authors: Pattabiraman, Sundararaghavan
Azad, Gajendra Kumar
Amen, Triana
Brielle, Shlomi
Park, Jung Eun
Sze, Siu Kwan
Meshorer, Eran
Kaganovich, Daniel
Keywords: Science::Biological sciences
Issue Date: 2020
Source: Pattabiraman, S., Azad, G. K., Amen, T., Brielle, S., Park, J. E., Sze, S. K., … Kaganovich, D. (2020). Vimentin protects differentiating stem cells from stress. Scientific Reports, 10, 19525-. doi:10.1038/s41598-020-76076-4
Journal: Scientific Reports
Abstract: Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian cells during embryogenesis, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in cell stiffness, cell motility, and cytoplasmic organization, yet it is widely considered to be dispensable for cellular function and organismal development. Here, we show that Vimentin plays a role in cellular stress response in differentiating cells, by recruiting aggregates, stress granules, and RNA-binding proteins, directing their elimination and asymmetric partitioning. In the absence of Vimentin, pluripotent embryonic stem cells fail to differentiate properly, with a pronounced deficiency in neuronal differentiation. Our results uncover a novel function for Vimentin, with important implications for development, tissue homeostasis, and in particular, stress response.
ISSN: 2045-2322
DOI: 10.1038/s41598-020-76076-4
Schools: School of Biological Sciences 
Rights: © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons .org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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