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dc.contributor.authorLuchetti, Alessandroen_US
dc.contributor.authorBota, Ayakaen_US
dc.contributor.authorWeitemier, Adamen_US
dc.contributor.authorMizuta, Kotaroen_US
dc.contributor.authorSato, Masaakien_US
dc.contributor.authorIslam, Tanviren_US
dc.contributor.authorMcHugh, Thomas J.en_US
dc.contributor.authorTashiro, Ayumuen_US
dc.contributor.authorHayashi, Yasunorien_US
dc.date.accessioned2021-01-26T06:12:13Z-
dc.date.available2021-01-26T06:12:13Z-
dc.date.issued2020-
dc.identifier.citationLuchetti, A., Bota, A., Weitemier, A., Mizuta, K., Sato, M., Islam, T., … Hayashi, Y. (2020). Two functionally distinct Serotonergic projections into hippocampus. The Journal of Neuroscience, 40(25), 4936-4944. doi:10.1523/jneurosci.2724-19.2020en_US
dc.identifier.issn0270-6474en_US
dc.identifier.urihttps://hdl.handle.net/10356/146082-
dc.description.abstractHippocampus receives dense serotonergic input specifically from raphe nuclei. However, what information is carried by this input and its impact on behavior has not been fully elucidated. Here we used in vivo two-photon imaging of activity of hippocampal median raphe projection fibers in behaving male and female mice and identified two distinct populations: one linked to reward delivery and the other to locomotion. Local optogenetic manipulation of these fibers confirmed a functional role for these projections in the modulation of reward-induced behavior. The diverse function of serotonergic inputs suggests a key role in integrating locomotion and reward information into the hippocampal CA1.SIGNIFICANCE STATEMENT Information constantly flows in the hippocampus, but only some of it is captured as a memory. One potential process that discriminates which information should be remembered is concomitance with reward. In this work, we report a neuromodulatory pathway, which delivers reward signal as well as locomotion signal to the hippocampal CA1. We found that the serotonergic system delivers heterogeneous input that may be integrated by the hippocampus to support its mnemonic functions. It is dynamically involved in regulating behavior through interaction with the hippocampus. Our results suggest that the serotonergic system interacts with the hippocampus in a dynamic and behaviorally specific manner to regulate reward-related information processing.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.language.isoenen_US
dc.relationMOE2015-T2-2-035en_US
dc.relationNMRC/OFIRG/0046/2017-00en_US
dc.relation.ispartofThe Journal of Neuroscienceen_US
dc.rights© 2020 The Author(s) (published by the Society for Neuroscience). This is an open-access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleTwo functionally distinct serotonergic projections into hippocampusen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doi10.1523/JNEUROSCI.2724-19.2020-
dc.description.versionPublished versionen_US
dc.identifier.pmid32414785-
dc.identifier.scopus2-s2.0-85086691287-
dc.identifier.issue25en_US
dc.identifier.volume40en_US
dc.identifier.spage4936en_US
dc.identifier.epage4944en_US
dc.subject.keywordsCA1en_US
dc.subject.keywordsCalcium Imagingen_US
dc.description.acknowledgementA.L. received a Japan Society for the Promotion of Science Postdoctoral Fellowship for Foreign Researchers and Japan Society for the Promotion of Science Grant-in-Aid for Japan Society for the Promotion of ScienceFellows (15F14409). This work was supported by RIKEN, RIKEN Presidents Fund, Grant-in-Aid for Scientific Research (A, 20240032, 16H02455) and for Scientific Research on Innovative Area “Foundation of Synapse and Neurocircuit Pathology” (22110006) and “Constructive understanding of multi-scale dynamism of neuropsychiatric disorders” (18H05434) from the MEXT, Japan, Human Frontier Science Program, Uehara Memorial Foundation, Naito Foundation, Taked Science Foundation, Japan Foundation for Applied Enzymology, Novartis Foundation (Japan) for the Promotion of Science, Research Foundation for Opto-Scienceand Technology, and Brain Science Foundation to Y.H. This work was also supported by Ministry of Education, Singapore, AcRF Tier 2 (MOE2015-T2-2-035), and National Medical Research Council, Singapore, OF-IRG(NMRC/OFIRG/0046/2017-00). We thank Drs. Kota Tamada and Toru Takumi for sharing unpublished data and materials.en_US
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