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Title: Two functionally distinct serotonergic projections into hippocampus
Authors: Luchetti, Alessandro
Bota, Ayaka
Weitemier, Adam
Mizuta, Kotaro
Sato, Masaaki
Islam, Tanvir
McHugh, Thomas J.
Tashiro, Ayumu
Hayashi, Yasunori
Keywords: Science::Biological sciences
Issue Date: 2020
Source: Luchetti, A., Bota, A., Weitemier, A., Mizuta, K., Sato, M., Islam, T., … Hayashi, Y. (2020). Two functionally distinct Serotonergic projections into hippocampus. The Journal of Neuroscience, 40(25), 4936-4944. doi:10.1523/jneurosci.2724-19.2020
Project: MOE2015-T2-2-035
Journal: The Journal of Neuroscience
Abstract: Hippocampus receives dense serotonergic input specifically from raphe nuclei. However, what information is carried by this input and its impact on behavior has not been fully elucidated. Here we used in vivo two-photon imaging of activity of hippocampal median raphe projection fibers in behaving male and female mice and identified two distinct populations: one linked to reward delivery and the other to locomotion. Local optogenetic manipulation of these fibers confirmed a functional role for these projections in the modulation of reward-induced behavior. The diverse function of serotonergic inputs suggests a key role in integrating locomotion and reward information into the hippocampal CA1.SIGNIFICANCE STATEMENT Information constantly flows in the hippocampus, but only some of it is captured as a memory. One potential process that discriminates which information should be remembered is concomitance with reward. In this work, we report a neuromodulatory pathway, which delivers reward signal as well as locomotion signal to the hippocampal CA1. We found that the serotonergic system delivers heterogeneous input that may be integrated by the hippocampus to support its mnemonic functions. It is dynamically involved in regulating behavior through interaction with the hippocampus. Our results suggest that the serotonergic system interacts with the hippocampus in a dynamic and behaviorally specific manner to regulate reward-related information processing.
ISSN: 0270-6474
DOI: 10.1523/JNEUROSCI.2724-19.2020
Rights: © 2020 The Author(s) (published by the Society for Neuroscience). This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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