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Title: Mechanisms and control measures of mature biofilm resistance to antimicrobial agents in the clinical context
Authors: Li, Yuanzhe
Xiao, Peng
Wang, Yilin
Hao, Yu
Keywords: Science::Biological sciences
Issue Date: 2020
Source: Li, Y., Xiao, P., Wang, Y., & Hao, Y. (2020). Mechanisms and control measures of mature biofilm resistance to antimicrobial agents in the clinical context. ACS Omega, 5(36), 22684-22690. doi:10.1021/acsomega.0c02294
Project: 122018-T1-001-077
Journal: ACS Omega
Abstract: Biofilms are the aggregation of micro-organisms, which are composed of extracellular polymeric substance (EPS) and many other biochemical components. Though they might be beneficial to some wastewater and soil treatment processes, they may expose chronic infection and risk to personal hygiene in the industrial as well as the clinical context. Despite having a well-established disinfection and hygiene monitoring program for the prevention of formation and growth, biofilm persistently remains in the medical settings because of its antibiotic resistance to antimicrobial agents and even the immune system. In this paper, the contributing factors of antibiotic resistance and the corresponding mechanisms, including heterogeneity inside biofilms, the roles of the EPS matrix, cell density, and quorum sensing, and cell mutability, are reviewed. Moreover, current clinical practice and strategic applications are also suggested to address the biofilm resistance issues.
ISSN: 2470-1343
DOI: 10.1021/acsomega.0c02294
Schools: School of Materials Science and Engineering 
Rights: © 2020 The Author(s). This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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