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Title: | One year structural and functional glaucoma progression after trabeculectomy | Authors: | Chua, Jacqueline Kadziauskienė, Aistė Wong, Damon Wing Kee Ašoklis, Rimvydas Lesinskas, Eugenijus Quang, Nguyen Duc Chong, Rachel Tan, Bingyao Girard, Michaël J. A. Mari, Jean Martial Crowston, Jonathan G. Aung, Tin Schmetterer, Leopold |
Keywords: | Science::Medicine | Issue Date: | 2020 | Source: | Chua, J., Kadziauskienė, A., Wong, D. W. K., Ašoklis, R., Lesinskas, E., Quang, N. D., . . . Schmetterer, L. (2020). One year structural and functional glaucoma progression after trabeculectomy. Scientific Reports, 10(1), 2808-. doi:10.1038/s41598-020-59792-9 | Project: | NMRC CG/C010A/2017 OFIRG/0048/2017 TA/MOH-000249-00/201 |
Journal: | Scientific Reports | Abstract: | We evaluated the changes in visual field mean deviation (VF MD) and retinal nerve fibre layer (RNFL) thickness in glaucoma patients undergoing trabeculectomy. One hundred patients were examined with VF and spectral-domain optical coherence tomography (OCT) before trabeculectomy and 4 follow-up visits over one year. Linear mixed models were used to investigate factors associated with VF and RNFL. VF improved during the first 3 months of follow-up (2.55 ± 1.06 dB/year) and worsened at later visits (−1.14 ± 0.29 dB/year). RNFL thickness reduced by −4.21 ± 0.25 µm/year from 1st month of follow-up. Eyes with an absence of initial VF improvement (β = 0.64; 0.30–0.98), RNFL thinning (β = 0.15; 0.08–0.23), increasing intraocular pressure (IOP; β = −0.11; −0.18 to −0.03) and severe glaucoma (β = −10.82; −13.61 to −8.02) were associated with VF deterioration. Eyes with VF deterioration (β = 0.19; 0.08–0.29), increasing IOP (β = −0.09; −0.17 to −0.01), and moderate (β = −6.33; −12.17 to −0.49) or severe glaucoma (β = −19.58; −24.63 to −14.52) were associated with RNFL thinning. Changes in RNFL structure and function occur over a 1-year follow-up period after trabeculectomy. Early VF improvement is more likely to occur in patients with mild/moderate glaucoma, whereas those with severe glaucoma show greater decline over one year. Our findings indicate that progression is observable using OCT, even in late-stage glaucoma. | URI: | https://hdl.handle.net/10356/146176 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-59792-9 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Rights: | © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | LKCMedicine Journal Articles |
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