Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146176
Title: One year structural and functional glaucoma progression after trabeculectomy
Authors: Chua, Jacqueline
Kadziauskienė, Aistė
Wong, Damon Wing Kee
Ašoklis, Rimvydas
Lesinskas, Eugenijus
Quang, Nguyen Duc
Chong, Rachel
Tan, Bingyao
Girard, Michaël J. A.
Mari, Jean Martial
Crowston, Jonathan G.
Aung, Tin
Schmetterer, Leopold
Keywords: Science::Medicine
Issue Date: 2020
Source: Chua, J., Kadziauskienė, A., Wong, D. W. K., Ašoklis, R., Lesinskas, E., Quang, N. D., . . . Schmetterer, L. (2020). One year structural and functional glaucoma progression after trabeculectomy. Scientific Reports, 10(1), 2808-. doi:10.1038/s41598-020-59792-9
Project: NMRC CG/C010A/2017
OFIRG/0048/2017
TA/MOH-000249-00/201
Journal: Scientific Reports 
Abstract: We evaluated the changes in visual field mean deviation (VF MD) and retinal nerve fibre layer (RNFL) thickness in glaucoma patients undergoing trabeculectomy. One hundred patients were examined with VF and spectral-domain optical coherence tomography (OCT) before trabeculectomy and 4 follow-up visits over one year. Linear mixed models were used to investigate factors associated with VF and RNFL. VF improved during the first 3 months of follow-up (2.55 ± 1.06 dB/year) and worsened at later visits (−1.14 ± 0.29 dB/year). RNFL thickness reduced by −4.21 ± 0.25 µm/year from 1st month of follow-up. Eyes with an absence of initial VF improvement (β = 0.64; 0.30–0.98), RNFL thinning (β = 0.15; 0.08–0.23), increasing intraocular pressure (IOP; β = −0.11; −0.18 to −0.03) and severe glaucoma (β = −10.82; −13.61 to −8.02) were associated with VF deterioration. Eyes with VF deterioration (β = 0.19; 0.08–0.29), increasing IOP (β = −0.09; −0.17 to −0.01), and moderate (β = −6.33; −12.17 to −0.49) or severe glaucoma (β = −19.58; −24.63 to −14.52) were associated with RNFL thinning. Changes in RNFL structure and function occur over a 1-year follow-up period after trabeculectomy. Early VF improvement is more likely to occur in patients with mild/moderate glaucoma, whereas those with severe glaucoma show greater decline over one year. Our findings indicate that progression is observable using OCT, even in late-stage glaucoma.
URI: https://hdl.handle.net/10356/146176
ISSN: 2045-2322
DOI: 10.1038/s41598-020-59792-9
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

Files in This Item:
File Description SizeFormat 
s41598-020-59792-9.pdf1.39 MBAdobe PDFThumbnail
View/Open

SCOPUSTM   
Citations 20

9
Updated on Mar 24, 2024

Web of ScienceTM
Citations 20

6
Updated on Oct 29, 2023

Page view(s)

285
Updated on Mar 28, 2024

Download(s) 50

68
Updated on Mar 28, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.