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Title: Genetic liability in individuals at ultra-high risk of psychosis : a comparison study of 9 psychiatric traits
Authors: Lim, Keane
Lam, Max
Huang, Hailiang
Liu, Jianjun
Lee, Jimmy Chee Keong
Keywords: Science::General
Issue Date: 2020
Source: Lim, K., Lam, M., Huang, H., Liu, J. & Lee, J. C. K. (2020). Genetic liability in individuals at ultra-high risk of psychosis : a comparison study of 9 psychiatric traits. PLoS ONE, 15(12), e0243104-.
Project: NMRC/TCR/003/2008
Journal: PLoS ONE
Abstract: Individuals at ultra-high risk (UHR) of psychosis are characterised by the emergence of attenuated psychotic symptoms and deterioration in functioning. In view of the high non-psychotic comorbidity and low rates of transition to psychosis, the specificity of the UHR status has been called into question. This study aims to (i) investigate if the UHR construct is associated with the genetic liability of schizophrenia or other psychiatric conditions; (ii) examine the ability of polygenic risk scores (PRS) to discriminate healthy controls from UHR, remission and conversion status. PRS was calculated for 210 youths (nUHR = 102, nControl = 108) recruited as part of the Longitudinal Youth at Risk Study (LYRIKS) using nine psychiatric traits derived from twelve large-scale psychiatric genome-wide association studies as discovery datasets. PRS was also examined to discriminate UHR-Healthy control status, and healthy controls from UHR remission and conversion status. Result indicated that schizophrenia PRS appears to best index the genetic liability of UHR, while trend level associations were observed for depression and cross-disorder PRS. Schizophrenia PRS discriminated healthy controls from UHR (R2 = 7.9%, p = 2.59 x 10-3, OR = 1.82), healthy controls from non-remitters (R2 = 8.1%, p = 4.90 x 10-4, OR = 1.90), and converters (R2 = 7.6%, p = 1.61 x 10-3, OR = 1.82), with modest predictive ability. A trend gradient increase in schizophrenia PRS was observed across categories. The association between schizophrenia PRS and UHR status supports the hypothesis that the schizophrenia polygenic liability indexes the risk for developing psychosis.
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0243104
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2020 Lim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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