Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/146268
Title: | Pulse wave velocity is associated with increased plasma oxLDL in ageing but not with FGF21 and habitual exercise | Authors: | Lee, Shuen Yee Burns, Stephen F. Ng, Kenneth K. C. Stensel, David J. Zhong, Liang Tan, Frankie H. Y. Chia, Kar Ling Fam, Kai Deng Yap, Margaret M. C. Yeo, Kwee Poo Yap, Eric Peng Huat Lim, Chin Leong |
Keywords: | Science::Medicine | Issue Date: | 2020 | Source: | Lee, S. Y., Burns, S. F., Ng, K. K. C., Stensel, D. J., Zhong, L., Tan, F. H. Y., . . . Lim, C. L. (2020). Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise. Antioxidants, 9(3), 221-. doi:10.3390/antiox9030221 | Project: | NMRC/OFIRG/0018/2016 L0412270 |
Journal: | Antioxidants | Abstract: | Fibroblast growth factor 21 (FGF21) and adiponectin increase the expression of genes involved in antioxidant pathways, but their roles in mediating oxidative stress and arterial stiffness with ageing and habitual exercise remain unknown. We explored the role of the FGF21-adiponectin axis in mediating oxidative stress and arterial stiffness with ageing and habitual exercise. Eighty age- and sex-matched healthy individuals were assigned to younger sedentary or active (18-36 years old, n = 20 each) and older sedentary or active (45-80 years old, n = 20 each) groups. Arterial stiffness was measured indirectly using pulse wave velocity (PWV). Fasted plasma concentrations of FGF21, adiponectin and oxidized low-density lipoprotein (oxLDL) were measured. PWV was 0.2-fold higher and oxLDL concentration was 25.6% higher (both p < 0.001) in older than younger adults, despite no difference in FGF21 concentration (p = 0.097) between age groups. PWV (p = 0.09) and oxLDL concentration (p = 0.275) did not differ between activity groups but FGF21 concentration was 9% lower in active than sedentary individuals (p = 0.011). Adiponectin concentration did not differ by age (p = 0.642) or exercise habits (p = 0.821). In conclusion, age, but not habitual exercise, was associated with higher oxidative stress and arterial stiffness. FGF21 and adiponectin did not differ between younger and older adults, meaning that it is unlikely that they mediate oxidative stress and arterial stiffness in healthy adults. | URI: | https://hdl.handle.net/10356/146268 | ISSN: | 2076-3921 | DOI: | 10.3390/antiox9030221 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) School of Physical and Mathematical Sciences |
Rights: | © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | LKCMedicine Journal Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
antioxidants-09-00221(1).pdf | 718.97 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
50
3
Updated on Mar 17, 2024
Web of ScienceTM
Citations
50
3
Updated on Oct 28, 2023
Page view(s)
240
Updated on Mar 17, 2024
Download(s) 50
76
Updated on Mar 17, 2024
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.