Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146271
Title: The association between tear film thickness as measured with OCT and symptoms and signs of dry eye disease : a pooled analysis of 6 clinical trials
Authors: Garhöfer, Gerhard
Dos Santos, Valentin Aranha
Stegmann, Hannes
Schmidl, Doreen
Adzhemian, Narine
Werkmeister, René M.
Schmetterer, Leopold
Keywords: Science::Medicine
Issue Date: 2020
Source: Garhöfer, G., Dos Santos, V. A., Stegmann, H., Schmidl, D., Adzhemian, N., Werkmeister, R. M., & Schmetterer, L. (2020). The association between tear film thickness as measured with OCT and symptoms and signs of dry eye disease : a pooled analysis of 6 clinical trials. Journal of Clinical Medicine, 9(11), 3791-. doi:10.3390/jcm9113791
Journal: Journal of Clinical Medicine
Abstract: Purpose: To determine the association between tear film thickness (TFT) as measured with ultra-high resolution optical coherence tomography (UHR-OCT) and signs and symptoms of dry eye disease (DED). Methods: A total of 450 eyes from 225 patients with DED from six different randomized clinical trials were included in this pooled analysis. In all subjects, TFT was measured with a custom-built UHR-OCT system. Symptoms of DED were quantified using a standardized Ocular Surface Disease Index (OSD)I questionnaire and clinical signs including tear film break up time (TFBUT) and Schirmer I test were assessed. Associations of the average TFT with OSDI, TFBUT, and Schirmer I test were calculated using a linear regression analysis. Results: The average TFT of the included sample (mean age, 45.0 ± 13.3 years; 65% female) was 4.2 ± 0.5 µm and the OSDI 36.2 ± 10.4. A significant negative correlation was found between TFT and OSDI (r = −0.36 to −0.31; p < 0.001). Tear break up time and Schirmer I test were not correlated with OSDI. Significant albeit weak correlations were found between TFT and TFBUT (r = 0.17 to 0.25; p < 0.01) as well as Schirmer I (r = 0.36 to 0.37; p < 0.001). Subgroup analysis revealed that the correlation was stronger in the subjects with abnormal Schirmer I (<15 mm; r = 0.50 to 0.54; p < 0.001). Conclusions: The present study demonstrates an objective measurement of TFT using a novel OCT approach for DED that correlates with symptoms and signs of DED. Our data are consistent with the idea that TFT represents the aqueous-deficient component of DED.
URI: https://hdl.handle.net/10356/146271
ISSN: 2077-0383
DOI: 10.3390/jcm9113791
Rights: © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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