Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146290
Title: Investigating the solid-state assembly of pharmaceutically-relevant N,N-dimethyl-O-thiocarbamates in the absence of labile hydrogen bonds
Authors: Tan, Davin
Ng, Zi Xuan
Ganguly, Rakesh
Li, Yongxin
Soo, Han Sen
Sharmarke Mohamed
García, Felipe
Keywords: Engineering
Issue Date: 2020
Source: Tan, D., Ng, Z. X., Ganguly, R., Li, Y., Soo, H. S., Sharmarke Mohamed, & García, F. (2020). Investigating the solid-state assembly of pharmaceutically-relevant N,N-dimethyl-O-thiocarbamates in the absence of labile hydrogen bonds. CrystEngComm, 22, 8290-8298. doi:10.1039/D0CE01336F
Project: RG 111/18
A1783c0003
A1783c0002
A1783c0007
M4080552
CIRA-2018-068
Journal: CrystEngComm
Abstract: There are many active pharmaceutical ingredients that lack N-H, O-H and S-H hydrogen-bond donor functional groups. N,N-disubstituted O-thiocarbamates are examples of molecules that display such a feature. Despite the desirable medicinal properties displayed by some N,N-disubstituted O-thiocarbamates, the study of the solid-state properties of these compounds has been relatively unexplored. Herein, we report the synthesis and analysis of the structures and properties of a series of N,N-dimethyl-O-thiocarbamates, and use X-ray diffraction techniques to gain insight into how these molecules self-assemble in the solid-state. As part of our work, we report for the first time the crystal structure of Tolnaftate, an active pharmaceutical ingredient that is indicated for the treatment of fungal infections. It was observed that the aryl-thiocarbamate C-O bonds are twisted such that the planar aryl and carbamate moieties are orthogonal. Such a non-planar molecular geometry affects the way the molecules pack and crystal structure analyses revealed four general modes in which the molecules can assemble in the solid-state, with some members of the series displaying isostructural relationships. Computational modelling of the cohesive energy densities in the crystals suggests that there is no single stacking type that is associated with greater stability. However, crystals with a combination of high packing index and π···π stacking interactions appear to display large cohesive energy densities. The lack of strong hydrogen bonding interactions in the crystals also leads to relatively low Young’s moduli that are within a narrow range of 10-15 GPa for all 14 crystal structures reported.
URI: https://hdl.handle.net/10356/146290
ISSN: 1466-8033
DOI: 10.1039/D0CE01336F
Rights: © 2020 The Author(s) (Royal Society of Chemistry). All rights reserved. This paper was published in CrystEngComm and is made available with permission of The Author(s) (Royal Society of Chemistry).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

Files in This Item:
File Description SizeFormat 
TEXT_revised_v3.pdf1.22 MBAdobe PDFView/Open
ESI_revised_DT_v3.pdf7.62 MBAdobe PDFView/Open

Page view(s)

197
Updated on Dec 1, 2022

Download(s) 50

31
Updated on Dec 1, 2022

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.