Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146292
Title: Self‐assembled single‐site nanozyme for tumor‐specific amplified cascade enzymatic therapy
Authors: Wang, Dongdong
Wu, Huihui
Wang, Changlai
Gu, Long
Chen, Hongzhong
Jana, Deblin
Feng, Lili
Liu, Jiawei
Wang, Xueying
Xu, Pengping
Guo, Zhen
Chen, Qianwang
Zhao, Yanli
Keywords: Science::Medicine
Issue Date: 2021
Source: Wang, D., Wu, H., Wang, C., Gu, L., Chen, H., Jana, D., ... Zhao, Y. (2021). Self‐assembled single‐site nanozyme for tumor‐specific amplified cascade enzymatic therapy. Angewandte Chemie International Edition, 60(6), 3001-3007. doi:10.1002/anie.202008868
Journal: Angewandte Chemie International Edition
Abstract: Nanomaterials with enzyme‐mimicking activity (nanozymes) show potential for therapeutic interventions. However, it remains a formidable challenge to selectively kill tumor cells through enzymatic reactions, while leaving normal cells unharmed. Herein, we present a new strategy based on a single‐site cascade enzymatic reaction for tumor‐specific therapy that avoids off‐target toxicity to normal tissues. A copper hexacyanoferrate (Cu‐HCF) nanozyme with active single‐site copper exhibited cascade enzymatic activity within the tumor microenvironment: Tumor‐specific glutathione oxidase activity by the Cu‐HCF single‐site nanozymes (SSNEs) led to the depletion of intracellular glutathione and the conversion of single‐site CuII species into CuI for subsequent amplified peroxidase activity through a Fenton‐type Harber–Weiss reaction. In this way, abundant highly toxic hydroxyl radicals were generated for tumor cell apoptosis. The results show that SSNEs could amplify the tumor‐killing efficacy of reactive oxygen species and suppress tumor growth in vivo.
URI: https://hdl.handle.net/10356/146292
ISSN: 1433-7851
DOI: 10.1002/anie.202008868
Rights: This is the accepted version of the following article: Wang, D., Wu, H., Wang, C., Gu, L., Chen, H., Jana, D., ... Zhao, Y. (2021). Self‐assembled single‐site nanozyme for tumor‐specific amplified cascade enzymatic therapy. Angewandte Chemie International Edition, 60(6), 3001-3007. doi:10.1002/anie.202008868, which has been published in final form at https://doi.org/10.1002/anie.202008868. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].
Fulltext Permission: embargo_20220215
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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