Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146313
Title: An ultrasmall SnFe2O4 nanozyme with endogenous oxygen generation and glutathione depletion for synergistic cancer therapy
Authors: Feng, Lili
Liu, Bin
Xie, Rui
Wang, Dongdong
Qian, Cheng
Zhou, Weiqiang
Liu, Jiawei
Jana, Deblin
Yang, Piaoping
Zhao, Yanli
Keywords: Science::Medicine
Issue Date: 2021
Source: Feng, L., Liu, B., Xie, R., Wang, D., Qian, C., Zhou, W., ... Zhao, Y. (2021). An ultrasmall SnFe2O4 nanozyme with endogenous oxygen generation and glutathione depletion for synergistic cancer therapy. Advanced Functional Materials, 31(5), 2006216-. doi:10.1002/adfm.202006216
Journal: Advanced Functional Materials 
Abstract: The tumor microenvironment (TME) with the characteristics of severe hypoxia, overexpressed glutathione (GSH), and high levels of hydrogen peroxide (H2O2) dramatically limits the antitumor efficiency by monotherapy. Herein, a novel TME-modulated nanozyme employing tin ferrite (SnFe2O4, abbreviated as SFO) is presented for simultaneous photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT). The as-fabricated SFO nanozyme demonstrates both catalase-like and GSH peroxidase-like activities. In the TME, the activation of H2O2 leads to the generation of hydroxyl radicals (•OH) in situ for CDT and the consumption of GSH to relieve antioxidant capability of the tumors. Meanwhile, the nanozyme can catalyze H2O2 to generate oxygen to meliorate the tumor hypoxia, which is beneficial to achieve better PDT. Furthermore, the SFO nanozyme irradiated with 808 nm laser displays a prominent phototherapeutic effect on account of the enhanced photothermal conversion efficiency (η = 42.3%) and highly toxic free radical production performance. This “all in one” nanozyme integrated with multiple treatment modalities, computed tomography, and magnetic resonance imaging properties, and persistent modulation of TME exhibits excellent tumor theranostic performance. This strategy may provide a new dimension for the design of other TME-based anticancer strategies.
URI: https://hdl.handle.net/10356/146313
ISSN: 1616-301X
DOI: 10.1002/adfm.202006216
Rights: This is the accepted version of the following article: Feng, L., Liu, B., Xie, R., Wang, D., Qian, C., Zhou, W., ... Zhao, Y. (2021). An ultrasmall SnFe2O4 nanozyme with endogenous oxygen generation and glutathione depletion for synergistic cancer therapy. Advanced Functional Materials, 31(5), 2006216-. doi:10.1002/adfm.202006216, which has been published in final form at https://doi.org/10.1002/adfm.202006216. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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