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Title: Clearable black phosphorus nanoconjugate for targeted cancer phototheranostics
Authors: Jana, Deblin
Jia, Shaorui
Bindra, Anivind Kaur
Xing, Pengyao
Ding, Dan
Zhao, Yanli
Keywords: Science::Medicine
Issue Date: 2020
Source: Jana, D., Jia, S., Bindra, A. K., Xing, P., Ding, D., & Zhao, Y. (2020). Clearable black phosphorus nanoconjugate for targeted cancer phototheranostics. ACS Applied Materials and Interfaces, 12(16), 18342–18351. doi:10.1021/acsami.0c02718
Journal: ACS Applied Materials and Interfaces
Abstract: Therapeutic efficacy of synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) is limited by complex conjugation chemistry, absorption wavelength mismatch and inadequate biodegradability of the PDT-PTT agents. Herein, we designed biocompatible copper sulfide nanodot anchored folic acid-modified black phosphorus nanosheets (BP-CuS-FA) to overcome these limitations, consequently enhancing the therapeutic efficiency of PDT-PTT. In vitro and in vivo assays reveal good biocompatibility and commendable tumor inhibition efficacy of the BP-CuS-FA nanoconjugate owing to synergistic PTT-PDT mediated by near-infrared laser irradiation. Importantly, folic acid unit could target folate receptor overexpressed cancer cells, leading to enhanced cellular uptake of BP-CuS-FA. BP-CuS-FA also exhibits significant contrast effect for photoacoustic imaging, permitting its in vivo tracking. The photodegradable character of BP-CuS-FA is associated with better renal clearance after the antitumor therapy in vivo. The present research may facilitate further development on straightforward approaches for targeted and imaging-guided synergistic PDT-PTT of cancer.
ISSN: 1944-8244
DOI: 10.1021/acsami.0c02718
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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