Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146318
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dc.contributor.authorWang, Xuanen_US
dc.contributor.authorLi, Menghuanen_US
dc.contributor.authorHou, Yanhuaen_US
dc.contributor.authorLi, Yananen_US
dc.contributor.authorYao, Xuemeien_US
dc.contributor.authorXue, Chenchengen_US
dc.contributor.authorFei, Yangen_US
dc.contributor.authorXiang, Yangen_US
dc.contributor.authorCai, Kaiyongen_US
dc.contributor.authorZhao, Yanlien_US
dc.contributor.authorLuo, Zhongen_US
dc.date.accessioned2021-02-09T05:53:44Z-
dc.date.available2021-02-09T05:53:44Z-
dc.date.issued2020-
dc.identifier.citationWang, X., Li, M., Hou, Y., Li, Y., Yao, X., Xue, C., ... Luo, Z. (2020). Tumor‐microenvironment‐activated in situ self‐assembly of sequentially responsive biopolymer for targeted photodynamic therapy. Advanced Functional Materials, 30(40), 2000229-. doi:10.1002/adfm.202000229en_US
dc.identifier.issn1616-301Xen_US
dc.identifier.urihttps://hdl.handle.net/10356/146318-
dc.description.abstractA sequentially responsive photosensitizer-integrated biopolymer is developed for tumor-specific photodynamic therapy, which is capable of forming long-retained aggregates in situ inside tumor tissues. Specifically, the photosensitizer zinc phthalocyanine (ZnPc) is conjugated with polyethylene glycol (PEG) via pH-labile maleic acid amide linker and then immobilized onto the hyaluronic acid (HA) chain using a redox-cleavable disulfide linker. The PEG segment can enhance blood circulation of the molecular carrier after intravenous administration and be shed after reaching the acidic tumor microenvironment, allowing the remaining fragment to self-assemble into large clusters in situ to avoid backward diffusion and improve tumor retention. This process is driven by hydrophobic interactions and does not require additional external actuation. The aggregates are then internalized by the tumor cells via HA-facilitated endocytosis, and the high glutathione level in tumor cells eventually leads to the intracellular release of ZnPc to facilitate its interaction with the subcellular lipid structures. This tumor-triggered morphology-based delivery platform is constructed with clinically tested components and could potentially be applied to other hydrophobic therapeutics.en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relation.ispartofAdvanced Functional Materialsen_US
dc.rightsThis is the accepted version of the following article: Wang, X., Li, M., Hou, Y., Li, Y., Yao, X., Xue, C., ... Luo, Z. (2020). Tumor‐microenvironment‐activated in situ self‐assembly of sequentially responsive biopolymer for targeted photodynamic therapy. Advanced Functional Materials, 30(40), 2000229-. doi:10.1002/adfm.202000229, which has been published in final form at https://doi.org/10.1002/adfm.202000229. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].en_US
dc.subjectScience::Medicineen_US
dc.titleTumor‐microenvironment‐activated in situ self‐assembly of sequentially responsive biopolymer for targeted photodynamic therapyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1002/adfm.202000229-
dc.description.versionAccepted versionen_US
dc.identifier.issue40en_US
dc.identifier.volume30en_US
dc.identifier.spage2000229en_US
dc.subject.keywordsPhotodynamic Biopolymersen_US
dc.subject.keywordsSelf-assemblyen_US
dc.description.acknowledgementX. Wang and M.H. Li contributed equally to this work. This work was financially supported by Natural Science Foundation of China (11832008, 51773023 and 21734002), National Key Technology R&D Program of China (2017YFB0702603 and 2016YFC1100300), Fundamental Research Funds for the Central Universities (2019CDQYSW005), Chongqing Outstanding Young Talent Supporting Program (CQYC201905072), Returning Overseas Scholar Innovation Program (CX2018062), Central University's Basic Scientific Research Business Fee Medical Integration Project (2019CDYGYB004). The work was also supported by the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03).en_US
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