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Title: Metal−organic framework derived multicomponent nanoagent as a reactive oxygen species amplifier for enhanced photodynamic therapy
Authors: Wang, Dongdong
Wu, Huihui
Yang, Guangbao
Qian, Cheng
Gu, Long
Wang, Hou
Zhou, Weiqiang
Liu, Jiawei
Wu, Yinglong
Zhang, Xiaodong
Guo, Zhen
Chen, Hongzhong
Jana, Deblin
Zhao, Yanli
Keywords: Science::Medicine
Issue Date: 2020
Source: Wang, D., Wu, H., Yang, G., Qian, C., Gu, L., Wang, H., ... Zhao, Y. (2020). Metal−organic framework derived multicomponent nanoagent as a reactive oxygen species amplifier for enhanced photodynamic therapy. ACS Nano, 14(10), 13500–13511. doi:10.1021/acsnano.0c05499
Journal: ACS Nano
Abstract: Intracellular antioxidants such as glutathione (GSH) play a critical role in protecting malignant tumor cells from apoptosis induced by reactive oxygen species (ROS) and in mechanisms of multidrug and radiation resistance. Herein, we rationally design two multicomponent self-assembled photodynamic therapy (PDT) nanoagents, that is, Glup-MFi-c and Glud-MFo-c, which consist of respective GSH-passivation and GSH-depletion linkers in metal−organic frameworks encapsulated with photosensitizers for a deeply comprehensive understanding of GSH-based tumor PDT. Multicomponent coordination, π−π stacking, and electrostatic interactions among metal ions, photosensitizers, and bridging linkers under the protection of a biocompatible polymer generate homogeneous nanoparticles with satisfied size, good colloid stability, and ultrahigh loading capacity. Compared to the GSH-passivated Glup-MFi-c, the GSH-depleted Glud-MFo-c shows pH-responsive release of photosensitizer and [FeIII(CN)6] linker in tumor cells to efficiently deplete intracellular GSH, thus amplifying the cell-killing efficiency of ROS and suppressing the tumor growth in vivo. This study demonstrates that Glud-MFo-c acts as a ROS amplifier, providing a useful strategy to deeply understand the role of GSH in combating cancer.
ISSN: 1936-0851
DOI: 10.1021/acsnano.0c05499
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: embargo_20211103
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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