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|Title:||Metal−organic framework derived multicomponent nanoagent as a reactive oxygen species amplifier for enhanced photodynamic therapy||Authors:||Wang, Dongdong
|Keywords:||Science::Medicine||Issue Date:||2020||Source:||Wang, D., Wu, H., Yang, G., Qian, C., Gu, L., Wang, H., ... Zhao, Y. (2020). Metal−organic framework derived multicomponent nanoagent as a reactive oxygen species amplifier for enhanced photodynamic therapy. ACS Nano, 14(10), 13500–13511. doi:10.1021/acsnano.0c05499||Journal:||ACS Nano||Abstract:||Intracellular antioxidants such as glutathione (GSH) play a critical role in protecting malignant tumor cells from apoptosis induced by reactive oxygen species (ROS) and in mechanisms of multidrug and radiation resistance. Herein, we rationally design two multicomponent self-assembled photodynamic therapy (PDT) nanoagents, that is, Glup-MFi-c and Glud-MFo-c, which consist of respective GSH-passivation and GSH-depletion linkers in metal−organic frameworks encapsulated with photosensitizers for a deeply comprehensive understanding of GSH-based tumor PDT. Multicomponent coordination, π−π stacking, and electrostatic interactions among metal ions, photosensitizers, and bridging linkers under the protection of a biocompatible polymer generate homogeneous nanoparticles with satisfied size, good colloid stability, and ultrahigh loading capacity. Compared to the GSH-passivated Glup-MFi-c, the GSH-depleted Glud-MFo-c shows pH-responsive release of photosensitizer and [FeIII(CN)6] linker in tumor cells to efficiently deplete intracellular GSH, thus amplifying the cell-killing efficiency of ROS and suppressing the tumor growth in vivo. This study demonstrates that Glud-MFo-c acts as a ROS amplifier, providing a useful strategy to deeply understand the role of GSH in combating cancer.||URI:||https://hdl.handle.net/10356/146323||ISSN:||1936-0851||DOI:||10.1021/acsnano.0c05499||Rights:||This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.0c05499||Fulltext Permission:||embargo_20211103||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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