Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146324
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dc.contributor.authorChua, Jacquelineen_US
dc.contributor.authorTham, Yih Chungen_US
dc.contributor.authorTan, Bingyaoen_US
dc.contributor.authorDevarajan, Kavyaen_US
dc.contributor.authorSchwarzhans, Florianen_US
dc.contributor.authorGan, Alfreden_US
dc.contributor.authorWong, Damon Wing Keeen_US
dc.contributor.authorCheung, Carol Y.en_US
dc.contributor.authorMajithia, Shivanien_US
dc.contributor.authorThakur, Sahilen_US
dc.contributor.authorFischer, Georgen_US
dc.contributor.authorVass, Clemensen_US
dc.contributor.authorCheng, Ching-Yuen_US
dc.contributor.authorSchmetterer, Leopolden_US
dc.date.accessioned2021-02-09T06:30:22Z-
dc.date.available2021-02-09T06:30:22Z-
dc.date.issued2019-
dc.identifier.citationChua, J., Tham, Y. C., Tan, B., Devarajan, K., Schwarzhans, F., Gan, A., . . . Schmetterer, L. (2019). Age-related changes of individual macular retinal layers among Asians. Scientific Reports, 9(1), 20352-. doi:10.1038/s41598-019-56996-6en_US
dc.identifier.issn2045-2322en_US
dc.identifier.other0000-0002-6474-5293-
dc.identifier.other0000-0002-6752-797X-
dc.identifier.other0000-0003-4756-9088-
dc.identifier.other0000-0003-0655-885X-
dc.identifier.urihttps://hdl.handle.net/10356/146324-
dc.description.abstractWe characterized the age-related changes of the intra-retinal layers measured with spectral-domain optical coherence tomography (SD-OCT; Cirrus high-definition OCT [Carl Zeiss Meditec]. The Singapore Epidemiology of Eye Diseases is a population-based, cross-sectional study of Chinese, Malays and Indians living in Singapore. Iowa Reference Algorithms (Iowa Institute for Biomedical Imaging) were used for intra-retinal layer segmentation and mean thickness of 10 intra-retinal layers rescaled with magnification correction using axial length value. Linear regression models were performed to investigate the association of retinal layers with risk factors. After excluding participants with history of diabetes or ocular diseases, high-quality macular SD-OCT images were available for 2,047 participants (44-89 years old). Most of the retinal layers decreased with age except for foveal retinal nerve fiber layer (RNFL) and the inner/outer segments of photoreceptors where they increased with age. Men generally had thicker retinal layers than women. Chinese have the thickest RNFL and retinal pigment epithelium amongst the ethnic groups. Axial length and refractive error remained correlated with retinal layers in spite of magnification correction. Our data show pronounced age-related changes in retinal morphology. Age, gender, ethnicity and axial length need be considered when establishing OCT imaging biomarkers for ocular or systemic disease.en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.language.isoenen_US
dc.relationCG/C010A/2017en_US
dc.relationCG/SERI/2010en_US
dc.relationSTaR/0003/2008en_US
dc.relationCIRG/1417/2015en_US
dc.relationCIRG/1488/2018en_US
dc.relationOFLCG/004a/2018en_US
dc.relationTA/MOH-000249–00/2018en_US
dc.relation.ispartofScientific Reportsen_US
dc.rights© 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.subjectScience::Medicineen_US
dc.titleAge-related changes of individual macular retinal layers among Asiansen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1038/s41598-019-56996-6-
dc.description.versionPublished versionen_US
dc.identifier.pmid31889143-
dc.identifier.scopus2-s2.0-85077195663-
dc.identifier.issue1en_US
dc.identifier.volume9en_US
dc.subject.keywordsGeriatricsen_US
dc.subject.keywordsThree-dimensional Imagingen_US
dc.description.acknowledgementThis work was funded by grants from the National Medical Research Council (CG/C010A/2017; CG/SERI/2010; STaR/0003/2008; CIRG/1417/2015, CIRG/1488/2018, OFLCG/004a/2018; and TA/MOH-000249–00/2018), Duke-NUS Medical School (Duke-NUS-KP(Coll)/2018/0009 A), and SingHealth Group Allied Health, Singapore. The sponsor or funding organization had no role in the design or conduct of this research.en_US
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