Please use this identifier to cite or link to this item:
Title: Age-related changes of individual macular retinal layers among Asians
Authors: Chua, Jacqueline
Tham, Yih Chung
Tan, Bingyao
Devarajan, Kavya
Schwarzhans, Florian
Gan, Alfred
Wong, Damon Wing Kee
Cheung, Carol Y.
Majithia, Shivani
Thakur, Sahil
Fischer, Georg
Vass, Clemens
Cheng, Ching-Yu
Schmetterer, Leopold
Keywords: Science::Medicine
Issue Date: 2019
Source: Chua, J., Tham, Y. C., Tan, B., Devarajan, K., Schwarzhans, F., Gan, A., . . . Schmetterer, L. (2019). Age-related changes of individual macular retinal layers among Asians. Scientific Reports, 9(1), 20352-. doi:10.1038/s41598-019-56996-6
Project: CG/C010A/2017
Journal: Scientific Reports 
Abstract: We characterized the age-related changes of the intra-retinal layers measured with spectral-domain optical coherence tomography (SD-OCT; Cirrus high-definition OCT [Carl Zeiss Meditec]. The Singapore Epidemiology of Eye Diseases is a population-based, cross-sectional study of Chinese, Malays and Indians living in Singapore. Iowa Reference Algorithms (Iowa Institute for Biomedical Imaging) were used for intra-retinal layer segmentation and mean thickness of 10 intra-retinal layers rescaled with magnification correction using axial length value. Linear regression models were performed to investigate the association of retinal layers with risk factors. After excluding participants with history of diabetes or ocular diseases, high-quality macular SD-OCT images were available for 2,047 participants (44-89 years old). Most of the retinal layers decreased with age except for foveal retinal nerve fiber layer (RNFL) and the inner/outer segments of photoreceptors where they increased with age. Men generally had thicker retinal layers than women. Chinese have the thickest RNFL and retinal pigment epithelium amongst the ethnic groups. Axial length and refractive error remained correlated with retinal layers in spite of magnification correction. Our data show pronounced age-related changes in retinal morphology. Age, gender, ethnicity and axial length need be considered when establishing OCT imaging biomarkers for ocular or systemic disease.
ISSN: 2045-2322
DOI: 10.1038/s41598-019-56996-6
Rights: © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

Files in This Item:
File Description SizeFormat 
s41598-019-56996-6.pdf3.75 MBAdobe PDFView/Open

Citations 50

Updated on Mar 5, 2021

Page view(s)

Updated on Jul 6, 2022

Download(s) 50

Updated on Jul 6, 2022

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.