Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146334
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dc.contributor.authorGrigg, Matthew J.en_US
dc.contributor.authorWilliam, Timothyen_US
dc.contributor.authorClemens, Emily G.en_US
dc.contributor.authorPatel, Kaajalen_US
dc.contributor.authorChandna, Arjunen_US
dc.contributor.authorWilkes, Christopher S.en_US
dc.contributor.authorBarber, Bridget E.en_US
dc.contributor.authorAnstey, Nicholas M.en_US
dc.contributor.authorDumler, J. Stephenen_US
dc.contributor.authorYeo, Tsin Wenen_US
dc.contributor.authorReller, Megan E.en_US
dc.date.accessioned2021-02-09T08:32:20Z-
dc.date.available2021-02-09T08:32:20Z-
dc.date.issued2020-
dc.identifier.citationGrigg, M. J., William, T., Clemens, E. G., Patel, K., Chandna, A., Wilkes, C. S., . . . Reller, M. E. (2020). Rickettsioses as major etiologies of unrecognized acute febrile illness, Sabah, East Malaysia. Emerging Infectious Diseases, 26(7), 1409-1419. doi:10.3201/eid2607.191722en_US
dc.identifier.issn1080-6040en_US
dc.identifier.urihttps://hdl.handle.net/10356/146334-
dc.description.abstractOrientia tsutsugamushi, spotted fever group rickettsioses, and typhus group rickettsioses (TGR) are reemerging causes of acute febrile illness (AFI) in Southeast Asia. To further delineate extent, we enrolled patients >4 weeks of age with nonmalarial AFI in Sabah, Malaysia, during 2013-2015. We confirmed rickettsioses (past or acute, IgG titer >160) in 126/354 (36%) patients. We confirmed acute rickettsioses (paired 4-fold IgG titer rise to >160) in 38/145 (26%) patients: 23 O. tsutsugamushi, 9 spotted fever group, 4 TGR, 1 O. tsutsugamushi/spotted fever group, and 1 O. tsutsugamushi/TGR. PCR results were positive in 11/319 (3%) patients. Confirmed rickettsioses were more common in male adults; agricultural/plantation work and recent forest exposure were risk factors. Dizziness and acute hearing loss but not eschars were reported more often with acute rickettsioses. Only 2 patients were treated with doxycycline. Acute rickettsioses are common (>26%), underrecognized, and untreated etiologies of AFI in East Malaysia; empirical doxycycline treatment should be considered.en_US
dc.language.isoenen_US
dc.relation.ispartofEmerging Infectious Diseasesen_US
dc.rights© 2020 The Author(s) (published by Public Domain). This is an open-access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.subjectScience::Medicineen_US
dc.titleRickettsioses as major etiologies of unrecognized acute febrile illness, Sabah, East Malaysiaen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.3201/eid2607.191722-
dc.description.versionPublished versionen_US
dc.identifier.pmid32568664-
dc.identifier.scopus2-s2.0-85086931246-
dc.identifier.issue7en_US
dc.identifier.volume26en_US
dc.identifier.spage1409en_US
dc.identifier.epage1419en_US
dc.subject.keywordsAcute Febrile Illnessen_US
dc.subject.keywordsDizzinessen_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:LKCMedicine Journal Articles
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