Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146344
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dc.contributor.authorSabir, Shekhen_US
dc.contributor.authorSubramoni, Sujathaen_US
dc.contributor.authorDas, Theerthankaren_US
dc.contributor.authorBlack, David StCen_US
dc.contributor.authorRice, Scott A.en_US
dc.contributor.authorKumar, Nareshen_US
dc.date.accessioned2021-02-10T04:45:18Z-
dc.date.available2021-02-10T04:45:18Z-
dc.date.issued2020-
dc.identifier.citationSabir, S., Subramoni, S., Das, T., Black, D. S., Rice, S. A., & Kumar, N. (2020). Design, Synthesis and Biological Evaluation of Novel Anthraniloyl-AMP Mimics as PQS Biosynthesis Inhibitors Against Pseudomonas aeruginosa Resistance. Molecules, 25(13), 3103-. doi:10.3390/molecules25133103en_US
dc.identifier.issn1420-3049en_US
dc.identifier.urihttps://hdl.handle.net/10356/146344-
dc.description.abstractThe Pseudomonas quinolone system (PQS) is one of the three major interconnected quorum sensing signaling systems in Pseudomonas aeruginosa. The virulence factors PQS and HHQ activate the transcription regulator PqsR (MvfR), which controls several activities in bacteria, including biofilm formation and upregulation of PQS biosynthesis. The enzyme anthraniloyl-CoA synthetase (PqsA) catalyzes the first and critical step in the biosynthesis of quinolones; therefore, it is an attractive target for the development of anti-virulence therapeutics against Pseudomonas resistance. Herein, we report the design and synthesis of novel triazole nucleoside-based anthraniloyl- adenosine monophosphate (AMP) mimics. These analogues had a major impact on the morphology of bacterial biofilms and caused significant reduction in bacterial aggregation and population density. However, the compounds showed only limited inhibition of PQS and did not exhibit any effect on pyocyanin production.en_US
dc.language.isoenen_US
dc.relation.ispartofMoleculesen_US
dc.rights© 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectScience::Chemistryen_US
dc.titleDesign, synthesis and biological evaluation of novel anthraniloyl-amp mimics as PQS biosynthesis inhibitors against pseudomonas aeruginosa resistanceen_US
dc.typeJournal Articleen
dc.contributor.researchSingapore Centre for Environmental Life Sciences and Engineeringen_US
dc.identifier.doi10.3390/molecules25133103-
dc.description.versionPublished versionen_US
dc.identifier.pmid32646050-
dc.identifier.scopus2-s2.0-85087841987-
dc.identifier.issue13en_US
dc.identifier.volume25en_US
dc.subject.keywordsPseudomonas Quinolone Systemen_US
dc.subject.keywordsQuorum Sensingen_US
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