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Title: Medicinal activities and nanomedicine delivery strategies for brucea javanica oil and its molecular components
Authors: Yoon, Bo Kyeong
Lim, Zheng Yi
Jeon, Won-Yong
Cho, Nam-Joon
Kim, Jeong Hoon
Jackman, Joshua A.
Keywords: Engineering::Materials
Issue Date: 2020
Source: Yoon, B. K., Lim, Z. Y., Jeon, W.-Y., Cho, N.-J., Kim, J. H., & Jackman, J. A. (2020). Medicinal Activities and Nanomedicine Delivery Strategies for Brucea javanica Oil and Its Molecular Components. Molecules, 25(22), 5414-. doi:10.3390/molecules25225414
Journal: Molecules
Abstract: Brucea javanica oil (BJO) is widely used in traditional Chinese medicine to treat various types of cancer and inflammatory diseases. There is significant interest in understanding the medicinal activities of BJO and its molecular components, especially quassinoids, and in exploring how they can be incorporated into nanomedicine delivery strategies for improved application prospects. Herein, we cover the latest progress in developing different classes of drug delivery vehicles, including nanoemulsions, liposomes, nanostructured lipid carriers, and spongosomes, to encapsulate BJO and purified quassinoids. An introduction to the composition and medicinal activities of BJO and its molecular components, including quassinoids and fatty acids, is first provided. Application examples involving each type of drug delivery vehicle are then critically presented. Future opportunities for nanomedicine delivery strategies in the field are also discussed and considered within the context of translational medicine needs and drug development processes.
ISSN: 1420-3049
DOI: 10.3390/molecules25225414
Rights: © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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