Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146346
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dc.contributor.authorSanchez-Bezanilla, Soniaen_US
dc.contributor.authorÅberg, N. Daviden_US
dc.contributor.authorCrock, Patriciaen_US
dc.contributor.authorWalker, Frederick R.en_US
dc.contributor.authorNilsson, Michaelen_US
dc.contributor.authorIsgaard, Jörgenen_US
dc.contributor.authorOng, Lin Kooien_US
dc.date.accessioned2021-02-10T05:23:43Z-
dc.date.available2021-02-10T05:23:43Z-
dc.date.issued2020-
dc.identifier.citationSanchez-Bezanilla, S., Åberg, N. D., Crock, P., Walker, F. R., Nilsson, M., Isgaard, J., & Ong, L. K. (2020). Growth Hormone Promotes Motor Function after Experimental Stroke and Enhances Recovery-Promoting Mechanisms within the Peri-Infarct Area. International Journal of Molecular Sciences, 21(2), 606-. doi:10.3390/ijms21020606en_US
dc.identifier.issn1661-6596en_US
dc.identifier.other0000-0003-2753-2691-
dc.identifier.other0000-0001-8664-0540-
dc.identifier.urihttps://hdl.handle.net/10356/146346-
dc.description.abstractMotor impairment is the most common and widely recognised clinical outcome after stroke. Current clinical practice in stroke rehabilitation focuses mainly on physical therapy, with no pharmacological intervention approved to facilitate functional recovery. Several studies have documented positive effects of growth hormone (GH) on cognitive function after stroke, but surprisingly, the effects on motor function remain unclear. In this study, photothrombotic occlusion targeting the motor and sensory cortex was induced in adult male mice. Two days post-stroke, mice were administered with recombinant human GH or saline, continuing for 28 days, followed by evaluation of motor function. Three days after initiation of the treatment, bromodeoxyuridine was administered for subsequent assessment of cell proliferation. Known neurorestorative processes within the peri-infarct area were evaluated by histological and biochemical analyses at 30 days post-stroke. This study demonstrated that GH treatment improves motor function after stroke by 50%-60%, as assessed using the cylinder and grid walk tests. Furthermore, the observed functional improvements occurred in parallel with a reduction in brain tissue loss, as well as increased cell proliferation, neurogenesis, increased synaptic plasticity and angiogenesis within the peri-infarct area. These findings provide new evidence about the potential therapeutic effects of GH in stroke recovery.en_US
dc.language.isoenen_US
dc.relation.ispartofInternational journal of molecular sciencesen_US
dc.rights© 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectScience::Medicineen_US
dc.titleGrowth hormone promotes motor function after experimental stroke and enhances recovery-promoting mechanisms within the peri-infarct areaen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.3390/ijms21020606-
dc.description.versionPublished versionen_US
dc.identifier.pmid31963456-
dc.identifier.scopus2-s2.0-85078314210-
dc.identifier.issue2en_US
dc.identifier.volume21en_US
dc.subject.keywordsIschemic Strokeen_US
dc.subject.keywordsGrowth Hormoneen_US
item.grantfulltextopen-
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