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Title: Growth hormone promotes motor function after experimental stroke and enhances recovery-promoting mechanisms within the peri-infarct area
Authors: Sanchez-Bezanilla, Sonia
Åberg, N. David
Crock, Patricia
Walker, Frederick R.
Nilsson, Michael
Isgaard, Jörgen
Ong, Lin Kooi
Keywords: Science::Medicine
Issue Date: 2020
Source: Sanchez-Bezanilla, S., Åberg, N. D., Crock, P., Walker, F. R., Nilsson, M., Isgaard, J., & Ong, L. K. (2020). Growth Hormone Promotes Motor Function after Experimental Stroke and Enhances Recovery-Promoting Mechanisms within the Peri-Infarct Area. International Journal of Molecular Sciences, 21(2), 606-. doi:10.3390/ijms21020606
Journal: International journal of molecular sciences
Abstract: Motor impairment is the most common and widely recognised clinical outcome after stroke. Current clinical practice in stroke rehabilitation focuses mainly on physical therapy, with no pharmacological intervention approved to facilitate functional recovery. Several studies have documented positive effects of growth hormone (GH) on cognitive function after stroke, but surprisingly, the effects on motor function remain unclear. In this study, photothrombotic occlusion targeting the motor and sensory cortex was induced in adult male mice. Two days post-stroke, mice were administered with recombinant human GH or saline, continuing for 28 days, followed by evaluation of motor function. Three days after initiation of the treatment, bromodeoxyuridine was administered for subsequent assessment of cell proliferation. Known neurorestorative processes within the peri-infarct area were evaluated by histological and biochemical analyses at 30 days post-stroke. This study demonstrated that GH treatment improves motor function after stroke by 50%-60%, as assessed using the cylinder and grid walk tests. Furthermore, the observed functional improvements occurred in parallel with a reduction in brain tissue loss, as well as increased cell proliferation, neurogenesis, increased synaptic plasticity and angiogenesis within the peri-infarct area. These findings provide new evidence about the potential therapeutic effects of GH in stroke recovery.
ISSN: 1661-6596
DOI: 10.3390/ijms21020606
Rights: © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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