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dc.contributor.authorDash, Rachitaen_US
dc.contributor.authorBhattacharjya, Surajiten_US
dc.identifier.citationDash, R., & Bhattacharjya, S. (2021). Thanatin : An emerging host defense antimicrobial peptide with multiple modes of action. International Journal of Molecular Sciences, 22(4). doi:10.3390/ijms22041522en_US
dc.description.abstractAntimicrobial peptides (AMPs) possess great potential for combating drug-resistant bacteria. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP which was first isolated from the insect Podisus maculiventris. The 21-residue-long thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi. Remarkably, thanatin was found to be highly potent in inhibiting the growth of bacteria and fungi at considerably low concentrations. Although thanatin was isolated around 25 years ago, only recently has there been a pronounced interest in understanding its mode of action and activity against drug-resistant bacteria. In this review, multiple modes of action of thanatin in killing bacteria and in vivo activity, therapeutic potential are discussed. This promising AMP requires further research for the development of novel molecules for the treatment of infections caused by drug resistant pathogens.en_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
dc.subjectScience::Biological sciencesen_US
dc.titleThanatin : An emerging host defense antimicrobial peptide with multiple modes of actionen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsAntimicorbial Peptides (AMPs)en_US
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