Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146368
Title: Thanatin : An emerging host defense antimicrobial peptide with multiple modes of action
Authors: Dash, Rachita
Bhattacharjya, Surajit
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Dash, R., & Bhattacharjya, S. (2021). Thanatin : An emerging host defense antimicrobial peptide with multiple modes of action. International Journal of Molecular Sciences, 22(4). doi:10.3390/ijms22041522
Journal: International Journal of Molecular Sciences 
Abstract: Antimicrobial peptides (AMPs) possess great potential for combating drug-resistant bacteria. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP which was first isolated from the insect Podisus maculiventris. The 21-residue-long thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi. Remarkably, thanatin was found to be highly potent in inhibiting the growth of bacteria and fungi at considerably low concentrations. Although thanatin was isolated around 25 years ago, only recently has there been a pronounced interest in understanding its mode of action and activity against drug-resistant bacteria. In this review, multiple modes of action of thanatin in killing bacteria and in vivo activity, therapeutic potential are discussed. This promising AMP requires further research for the development of novel molecules for the treatment of infections caused by drug resistant pathogens.
URI: https://hdl.handle.net/10356/146368
ISSN: 1422-0067
DOI: 10.3390/ijms22041522
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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