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Title: Artificial intelligence in sepsis early prediction and diagnosis using unstructured data in healthcare
Authors: Goh, Kim Huat
Wang, Le
Yeow, Adrian Yong Kwang
Poh, Hermione
Li, Ke
Yeow, Joannas Jie Lin
Tan, Gamaliel Yu Heng
Keywords: Science
Issue Date: 2021
Source: Goh, K. H., Wang, L., Yeow, A. Y. K., Poh, H., Li, K., Yeow, J. J. L., & Tan, G. Y. H. (2021). Artificial intelligence in sepsis early prediction and diagnosis using unstructured data in healthcare. Nature Communications, 12(1), 711-. doi:10.1038/s41467-021-20910-4
Journal: Nature Communications
Abstract: Sepsis is a leading cause of death in hospitals. Early prediction and diagnosis of sepsis, which is critical in reducing mortality, is challenging as many of its signs and symptoms are similar to other less critical conditions. We develop an artificial intelligence algorithm, SERA algorithm, which uses both structured data and unstructured clinical notes to predict and diagnose sepsis. We test this algorithm with independent, clinical notes and achieve high predictive accuracy 12 hours before the onset of sepsis (AUC 0.94, sensitivity 0.87 and specificity 0.87). We compare the SERA algorithm against physician predictions and show the algorithm’s potential to increase the early detection of sepsis by up to 32% and reduce false positives by up to 17%. Mining unstructured clinical notes is shown to improve the algorithm’s accuracy compared to using only clinical measures for early warning 12 to 48 hours before the onset of sepsis.
ISSN: 2041-1723
DOI: 10.1038/s41467-021-20910-4
Rights: © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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