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dc.contributor.authorWu, Lien_US
dc.contributor.authorHan, Yuqiuen_US
dc.contributor.authorZheng, Zhipengen_US
dc.contributor.authorPeng, Guopingen_US
dc.contributor.authorLiu, Pingen_US
dc.contributor.authorYue, Siqingen_US
dc.contributor.authorZhu, Shuaien_US
dc.contributor.authorChen, Junen_US
dc.contributor.authorLv, Hanyingen_US
dc.contributor.authorShao, Lifangen_US
dc.contributor.authorSheng, Yanen_US
dc.contributor.authorWang, Yulanen_US
dc.contributor.authorLi, Liangen_US
dc.contributor.authorLi, Lanjuanen_US
dc.contributor.authorWang, Baohongen_US
dc.identifier.citationWu, L., Han, Y., Zheng, Z., Peng, G., Liu, P., Yue, S., . . . Wang, B. (2021). Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay. Nutrients, 13(1), 228-. doi:10.3390/nu13010228en_US
dc.description.abstractIntimate metabolic host-microbiome crosstalk regulates immune, metabolic, and neuronal response in health and disease, yet remains untapped for biomarkers or intervention for disease. Our recent study identified an altered microbiome in patients with pre-onset amnestic mild cognitive impairment (aMCI) and dementia Alzheimer's disease (AD). Thus, we aimed to characterize the gut microbial metabolites among AD, aMCI, and healthy controls (HC). Here, a cohort of 77 individuals (22 aMCI, 27 AD, and 28 HC) was recruited. With the use of liquid-chromatography/gas chromatography mass spectrometry metabolomics profiling, we identified significant differences between AD and HC for tryptophan metabolites, short-chain fatty acids (SCFAs), and lithocholic acid, the majority of which correlated with altered microbiota and cognitive impairment. Notably, tryptophan disorders presented in aMCI and SCFAs decreased progressively from aMCI to AD. Importantly, indole-3-pyruvic acid, a metabolite from tryptophan, was identified as a signature for discrimination and prediction of AD, and five SCFAs for pre-onset and progression of AD. This study showed fecal-based gut microbial signatures were associated with the presence and progression of AD, providing a potential target for microbiota or dietary intervention in AD prevention and support for the host-microbe crosstalk signals in AD pathophysiology.en_US
dc.rights© 2021 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
dc.titleAltered gut microbial metabolites in amnestic mild cognitive impairment and alzheimer's disease : signals in host-microbe interplayen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.researchSingapore Phenome Centreen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsAlzheimer’s Diseaseen_US
dc.subject.keywordsFecal Metabolomicsen_US
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