Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorJeon, Won-Yongen_US
dc.contributor.authorMun, Seyoungen_US
dc.contributor.authorNg, Wei Bengen_US
dc.contributor.authorKang, Keunsooen_US
dc.contributor.authorHan, Kyudongen_US
dc.contributor.authorHwang, Sohyunen_US
dc.contributor.authorKim, Hyug-Hanen_US
dc.contributor.authorLee, Jae Hoen_US
dc.identifier.citationJeon, W.-Y., Mun, S., Ng, W. B., Kang, K., Han, K., Hwang, S., . . . Lee, J. H. (2021). Modulation of Human Mesenchymal Stem Cells by Electrical Stimulation Using an Enzymatic Biofuel Cell. Catalysts, 11(1), 62-. doi:10.3390/catal11010062en_US
dc.description.abstractEnzymatic biofuel cells (EBFCs) have excellent potential as components in bioelectronic devices, especially as active biointerfaces to regulate stem cell behavior for regenerative medicine applications. However, it remains unclear to what extent EBFC-generated electrical stimulation can regulate the functional behavior of human adipose-derived mesenchymal stem cells (hAD-MSCs) at the morphological and gene expression levels. Herein, we investigated the effect of EBFC-generated electrical stimulation on hAD-MSC cell morphology and gene expression using next-generation RNA sequencing. We tested three different electrical currents, 127 ± 9, 248 ± 15, and 598 ± 75 nA/cm2, in mesenchymal stem cells. We performed transcriptome profiling to analyze the impact of EBFC-derived electrical current on gene expression using next generation sequencing (NGS). We also observed changes in cytoskeleton arrangement and analyzed gene expression that depends on the electrical stimulation. The electrical stimulation of EBFC changes cell morphology through cytoskeleton re-arrangement. In particular, the results of whole transcriptome NGS showed that specific gene clusters were up-or down-regulated depending on the magnitude of applied electrical current of EBFC. In conclusion, this study demonstrates that EBFC-generated electrical stimulation can influence the morphological and gene expression properties of stem cells; such capabilities can be useful for regenerative medicine applications such as bioelectronic devices.en_US
dc.rights© 2021 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
dc.titleModulation of human mesenchymal stem cells by electrical stimulation using an enzymatic biofuel cellen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsHuman Adipose-derived Mesenchymal Stem Cellen_US
dc.subject.keywordsEnzymatic Biofuel Cellen_US
item.fulltextWith Fulltext-
Appears in Collections:MSE Journal Articles
Files in This Item:
File Description SizeFormat 
catalysts-11-00062.pdf2.54 MBAdobe PDFView/Open

Page view(s)

Updated on Aug 18, 2022


Updated on Aug 18, 2022

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.