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Title: Near-infrared light-sensitive liposomes for enhanced plasmid DNA transfection
Authors: Wiraja, Christian
Mathiyazhakan, Malathi
Movahedi, Fatemeh
Upputuri, Paul Kumar
Cheng, Yingying
Pramanik, Manojit
Yang, Liang
Becker, David Laurence
Xu, Chenjie
Keywords: Engineering::Bioengineering
Issue Date: 2016
Source: Wiraja, C., Mathiyazhakan, M., Movahedi, F., Upputuri, P. K., Cheng, Y., Pramanik, M., ... Xu, C. (2016). Near-infrared light-sensitive liposomes for enhanced plasmid DNA transfection. Bioengineering and Translational Medicine, 1(3), 357-364. doi:10.1002/btm2.10020
Journal: Bioengineering and Translational Medicine
Abstract: Near-infrared (NIR) light-responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial organ or tissue (e.g., skin). This work describes the development of NIR-responsive liposomes by incorporating gold nanostars within liposomes composed of Phospholipon 90 g and cholesterol. Following cellular delivery, photothermal effect around the gold nanostar upon NIR stimulation induces microcavitation and liposome phase transition which consequently triggers the release of encapsulated molecules. Taking GFP plasmid as an example, we demonstrate enhanced gene transfection into fibroblasts following NIR treatment.
ISSN: 2380-6761
DOI: 10.1002/btm2.10020
Rights: © 2016 The Authors. Bioengineering & Translational Medicine is published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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