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dc.contributor.authorMa, Zhimingen_US
dc.identifier.citationMa, Z. (2021). Biomolecular condensation-mediated actin remodeling in plant innate immunity. Doctoral thesis, Nanyang Technological University, Singapore.en_US
dc.description.abstractUpon bacterial invasion, the plant host acutely remodels the actin cytoskeleton to coordinate defense mechanisms. However, the molecular mechanisms by which plant triggers rapid actin remodeling remain enigmatic. In my PhD study, we have found that plant actin nucleation factor, type-I formin, serves as the molecular sensor that responds to bacterial virulence factors for actin remodeling during host immune signalling. Two types of virulence factors of Xanthomonas campestris pv. campestris (Xcc), diffusible signal factor (DSF), and pathogen-associated molecular pattern (PAMP), flagellin (flg22), regulate actin assembly through oppositely tuning the type-I formin nano-clustering on the plasma membrane (PM). The formin nano-clustering and nucleation activity depend highly on the mechanical regulation by the cell wall-PM-actin cytoskeleton continuum during both DSF and PAMP signalling. Specifically, DSF attenuates formin nano-clustering and causes reduced actin assembly by perturbing the integrity of cell wall. While PAMPs trigger the nano-clustering of formin in a PM nanodomain assembly factor Remorin-dependent manner. Together, our results have unravelled a central molecular mechanism for rapid actin remodeling during plant-bacteria interactions, in which bacterial signalling molecules finetune plant type-I formin condensation in a host mechanical structure-dependent manner.en_US
dc.publisherNanyang Technological Universityen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).en_US
dc.subjectScience::Biological sciences::Botanyen_US
dc.subjectScience::Biological sciences::Biochemistryen_US
dc.titleBiomolecular condensation-mediated actin remodeling in plant innate immunityen_US
dc.typeThesis-Doctor of Philosophyen_US
dc.contributor.supervisorMiao Yansongen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.degreeDoctor of Philosophyen_US
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