Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146525
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dc.contributor.authorLiu, Zong-Yuanen_US
dc.contributor.authorLi, Boen_US
dc.contributor.authorZhao, Zi-Longen_US
dc.contributor.authorXu, Guang-Kuien_US
dc.contributor.authorFeng, Xi-Qiaoen_US
dc.contributor.authorGao, Huajianen_US
dc.date.accessioned2021-02-23T06:45:22Z-
dc.date.available2021-02-23T06:45:22Z-
dc.date.issued2020-
dc.identifier.citationLiu, Z.-Y., Li, B., Zhao, Z.-L., Xu, G.-K., Feng, X.-Q., & Gao, H. (2020). Mesoscopic dynamic model of epithelial cell division with cell-cell junction effects. Physical Review E, 102(1), 012405-. doi:10.1103/physreve.102.012405en_US
dc.identifier.issn2470-0045en_US
dc.identifier.urihttps://hdl.handle.net/10356/146525-
dc.description.abstractCell division is central for embryonic development, tissue morphogenesis, and tumor growth. Experiments have evidenced that mitotic cell division is manipulated by the intercellular cues such as cell-cell junctions. However, it still remains unclear how these cortical-associated cues mechanically affect the mitotic spindle machinery, which determines the position and orientation of the cell division. In this paper, a mesoscopic dynamic cell division model is established to explore the integrated regulations of cortical polarity, microtubule pulling forces, cell deformability, and internal osmotic pressure. We show that the distributed pulling forces of astral microtubules play a key role in encoding the instructive cortical cues to orient and position the spindle of a dividing cell. The present model can not only predict the spindle orientation and position, but also capture the morphological evolution of cell rounding. The theoretical results agree well with relevant experiments both qualitatively and quantitatively. This work sheds light on the mechanical linkage between cell cortex and mitotic spindle, and holds potential in regulating cell division and sculpting tissue morphology.en_US
dc.language.isoenen_US
dc.relation.ispartofPhysical Review Een_US
dc.rights© 2020 American Physical Society (APS). All rights reserved. This paper was published in Physical Review E and is made available with permission of American Physical Society (APS).en_US
dc.subjectScience::Physicsen_US
dc.titleMesoscopic dynamic model of epithelial cell division with cell-cell junction effectsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.contributor.organizationInstitute of High Performance Computing, A*STARen_US
dc.identifier.doi10.1103/PhysRevE.102.012405-
dc.description.versionPublished versionen_US
dc.identifier.pmid32794908-
dc.identifier.scopus2-s2.0-85089487070-
dc.identifier.issue1en_US
dc.identifier.volume102en_US
dc.subject.keywordsCell Divisionen_US
dc.subject.keywordsCell Polarityen_US
item.grantfulltextopen-
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