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Title: Mesoscopic dynamic model of epithelial cell division with cell-cell junction effects
Authors: Liu, Zong-Yuan
Li, Bo
Zhao, Zi-Long
Xu, Guang-Kui
Feng, Xi-Qiao
Gao, Huajian
Keywords: Science::Physics
Issue Date: 2020
Source: Liu, Z.-Y., Li, B., Zhao, Z.-L., Xu, G.-K., Feng, X.-Q., & Gao, H. (2020). Mesoscopic dynamic model of epithelial cell division with cell-cell junction effects. Physical Review E, 102(1), 012405-. doi:10.1103/physreve.102.012405
Journal: Physical Review E
Abstract: Cell division is central for embryonic development, tissue morphogenesis, and tumor growth. Experiments have evidenced that mitotic cell division is manipulated by the intercellular cues such as cell-cell junctions. However, it still remains unclear how these cortical-associated cues mechanically affect the mitotic spindle machinery, which determines the position and orientation of the cell division. In this paper, a mesoscopic dynamic cell division model is established to explore the integrated regulations of cortical polarity, microtubule pulling forces, cell deformability, and internal osmotic pressure. We show that the distributed pulling forces of astral microtubules play a key role in encoding the instructive cortical cues to orient and position the spindle of a dividing cell. The present model can not only predict the spindle orientation and position, but also capture the morphological evolution of cell rounding. The theoretical results agree well with relevant experiments both qualitatively and quantitatively. This work sheds light on the mechanical linkage between cell cortex and mitotic spindle, and holds potential in regulating cell division and sculpting tissue morphology.
ISSN: 2470-0045
DOI: 10.1103/PhysRevE.102.012405
Schools: School of Mechanical and Aerospace Engineering 
Organisations: Institute of High Performance Computing, A*STAR
Rights: © 2020 American Physical Society (APS). All rights reserved. This paper was published in Physical Review E and is made available with permission of American Physical Society (APS).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles

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