Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146529
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dc.contributor.authorSharma, Arunimaen_US
dc.contributor.authorIshak, Noreenen_US
dc.contributor.authorTeoh, Swee-Hinen_US
dc.contributor.authorPramanik, Manojiten_US
dc.date.accessioned2021-02-23T09:25:24Z-
dc.date.available2021-02-23T09:25:24Z-
dc.date.issued2020-
dc.identifier.citationSharma, A., Ishak, N., Teoh, S.-H., & Pramanik, M. (2020). High resolution, label-free photoacoustic imaging of live chicken embryo developing in bioengineered eggshell. Journal of Biophotonics, 13(4), e201960108-. doi:10.1002/jbio.201960108en_US
dc.identifier.issn1864-0648en_US
dc.identifier.other0000-0001-7219-7509-
dc.identifier.other0000-0003-2865-5714-
dc.identifier.urihttps://hdl.handle.net/10356/146529-
dc.description.abstractChicken embryos have been proven to be an attractive vertebrate model for biomedical research. They have helped in making significant contributions for advancements in various fields like developmental biology, cancer research and cardiovascular studies. However, a non-invasive, label-free method of imaging live chicken embryo at high resolution still needs to be developed and optimized. In this work, we have shown the potential of photoacoustic tomography (PAT) for imaging live chicken embryos cultured in bioengineered eggshells. Laser pulses at wavelengths of 532 and 740 nm were used for attaining cross-sectional images of chicken embryos at different developmental stages. Cross-sections along different depths were imaged to gain knowledge of the relative depth of different vessels and organs. Due to high optical absorption of vasculature and embryonic eye, images with good optical contrast could be acquired using this method. We have thus reported a label-free method of performing cross-sectional imaging of chicken embryos at high resolution demonstrating the capacity of PAT as a promising tool for avian embryo imaging.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipMinistry of Health (MOH)en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Biophotonicsen_US
dc.rightsThis is the peer reviewed version of the following article: Sharma, A., Ishak, N., Teoh, S.-H., & Pramanik, M. (2020). High resolution, label-free photoacoustic imaging of live chicken embryo developing in bioengineered eggshell. Journal of Biophotonics, 13(4), e201960108-. doi:10.1002/jbio.201960108, which has been published in final form at https://doi.org/10.1002/jbio.201960108. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.subjectEngineering::Bioengineeringen_US
dc.titleHigh resolution, label-free photoacoustic imaging of live chicken embryo developing in bioengineered eggshellen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1002/jbio.201960108-
dc.description.versionAccepted versionen_US
dc.identifier.pmid31908159-
dc.identifier.scopus2-s2.0-85077868410-
dc.identifier.issue4en_US
dc.identifier.volume13en_US
dc.identifier.spagee201960108en_US
dc.subject.keywordsBioengineered Eggshellen_US
dc.subject.keywordsPhotoacoustic Imagingen_US
dc.description.acknowledgementThe research was supported by a Tier 1 grant funded by the Ministry of Education in Singapore (RG144/18: M4012098) and by the Singapore Ministry of Health’s National Medical Research Council (NMRC/OFIRG/0005/2016: M4062012). SH Teoh greatly acknowledges the support of NTU start up grant M4081399. Authors have no relevant financial interest in the manuscript and no other potential conflict of interest to disclose.en_US
item.grantfulltextembargo_20210430-
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