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Title: Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy
Authors: Jiang, Yuyan
Zhao, Xuhui
Huang, Jiaguo
Li, Jingchao
Upputuri, Paul Kumar
Sun, He
Han, Xiao
Pramanik, Manojit
Miao, Yansong
Duan, Hongwei
Pu, Kanyi
Zhang, Ruiping
Keywords: Engineering::Bioengineering
Issue Date: 2020
Source: Jiang, Y., Zhao, X., Huang, J., Li, J., Upputuri, P. K., Sun, H., ... Zhang, R. (2020). Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy. Nature Communications, 11(1), 1857-. doi:10.1038/s41467-020-15730-x
Journal: Nature Communications
Abstract: Despite its growing promise in cancer treatment, ferrotherapy has low therapeutic efficacy due to compromised Fenton catalytic efficiency in tumor milieu. We herein report a hybrid semiconducting nanozyme (HSN) with high photothermal conversion efficiency for photoacoustic (PA) imaging-guided second near-infrared photothermal ferrotherapy. HSN comprises an amphiphilic semiconducting polymer as photothermal converter, PA emitter and iron-chelating Fenton catalyst. Upon photoirradiation, HSN generates heat not only to induce cytotoxicity but also to enhance Fenton reaction. The increased ·OH generation promotes both ferroptosis and apoptosis, oxidizes HSN (42 nm) and transforms it into tiny segments (1.7 nm) with elevated intratumoral permeability. The non-invasive seamless synergism leads to amplified therapeutic effects including a deep ablation depth (9 mm), reduced expression of metastasis-related proteins and inhibition of metastasis from primary tumor to distant organs. Thereby, our study provides a generalized nanozyme strategy to compensate both ferrotherapy and phototherapeutics for complete tumor regression.
ISSN: 2041-1723
DOI: 10.1038/s41467-020-15730-x
Rights: © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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