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https://hdl.handle.net/10356/146532
Title: | Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy | Authors: | Jiang, Yuyan Zhao, Xuhui Huang, Jiaguo Li, Jingchao Upputuri, Paul Kumar Sun, He Han, Xiao Pramanik, Manojit Miao, Yansong Duan, Hongwei Pu, Kanyi Zhang, Ruiping |
Keywords: | Engineering::Bioengineering | Issue Date: | 2020 | Source: | Jiang, Y., Zhao, X., Huang, J., Li, J., Upputuri, P. K., Sun, H., ... Zhang, R. (2020). Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy. Nature Communications, 11(1), 1857-. doi:10.1038/s41467-020-15730-x | Journal: | Nature Communications | Abstract: | Despite its growing promise in cancer treatment, ferrotherapy has low therapeutic efficacy due to compromised Fenton catalytic efficiency in tumor milieu. We herein report a hybrid semiconducting nanozyme (HSN) with high photothermal conversion efficiency for photoacoustic (PA) imaging-guided second near-infrared photothermal ferrotherapy. HSN comprises an amphiphilic semiconducting polymer as photothermal converter, PA emitter and iron-chelating Fenton catalyst. Upon photoirradiation, HSN generates heat not only to induce cytotoxicity but also to enhance Fenton reaction. The increased ·OH generation promotes both ferroptosis and apoptosis, oxidizes HSN (42 nm) and transforms it into tiny segments (1.7 nm) with elevated intratumoral permeability. The non-invasive seamless synergism leads to amplified therapeutic effects including a deep ablation depth (9 mm), reduced expression of metastasis-related proteins and inhibition of metastasis from primary tumor to distant organs. Thereby, our study provides a generalized nanozyme strategy to compensate both ferrotherapy and phototherapeutics for complete tumor regression. | URI: | https://hdl.handle.net/10356/146532 | ISSN: | 2041-1723 | DOI: | 10.1038/s41467-020-15730-x | Schools: | School of Chemical and Biomedical Engineering School of Biological Sciences |
Rights: | © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SCBE Journal Articles |
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