Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146533
Title: Redox-activatable and acid-enhanced nanotheranostics for second near-infrared photoacoustic tomography and combined photothermal tumor therapy
Authors: Wang, Zhimin
Zhen, Xu
Upputuri, Paul Kumar
Jiang, Yuyan
Lau, Junwei
Pramanik, Manojit
Pu, Kanyi
Xing, Bengang
Keywords: Engineering::Bioengineering
Issue Date: 2019
Source: Wang, Z., Zhen, X., Upputuri, P. K., Jiang, Y., Lau, J., Pramanik, M., ... Xing, B. (2019). Redox-activatable and acid-enhanced nanotheranostics for second near-infrared photoacoustic tomography and combined photothermal tumor therapy. ACS Nano, 13(5), 5816-5825. doi:10.1021/acsnano.9b01411
Journal: ACS Nano
Abstract: Tumor phototheranostics in the second near-infrared window (NIR-II, 1000-1700 nm) holds great promise due to high spatiotemporal precision, enhanced penetration depth, and therapeutic efficacy. However, current "always-on" NIR-II phototheranostic agents remain restricted by the inherent nonspecificity from the pseudosignal readout and undesirable treatment-related side effects. To address these challenges, herein we explore an activatable and biocompatible nanotheranostics that generates diagnostic and therapeutic effects only after specific activation and enhancement by tumor microenvironmental redox and acid while keeping silent at normal tissues. Such an intelligent "turn-on" chromogenic nanotheranostics allows in vivo nearly zero-background photoacoustic tomography (PAT) and combined effective photothermal tumor therapy (PTT) both in the NIR-II range with minimal adverse effects. In light of the high sensitivity, superior penetration depth, and biocompatibility, this stimuli-activatable NIR-II photo-nanotheranostics provides broad prospects for the investigation and intervention of deep-tissue redox and acid-associated physiological and pathological events.
URI: https://hdl.handle.net/10356/146533
ISSN: 1936-086X
DOI: 10.1021/acsnano.9b01411
Fulltext Permission: none
Fulltext Availability: No Fulltext
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