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|Title:||In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system||Authors:||Rajendran, Praveenbalaji
Dienzo, Rhonnie Austria
|Keywords:||Engineering::Bioengineering||Issue Date:||2020||Source:||Rajendran, P., Sahu, S., Dienzo, R. A., & Pramanik, M. (2020). In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system. Proceedings of SPIE - Photons Plus Ultrasound: Imaging and Sensing 2020, 11240, 107-. doi:10.1117/12.2543892||Abstract:||Assessment of morphological changes in cerebral venous sinus of small animal models is important to gain insights of various disease conditions such as intracranial hypotension, Idiopathic intracranial hypertension (IIH), Cerebral venous sinus thrombosis, subdural hematoma etc. Photoacoustic Tomography (PAT), a fast-growing non-invasive hybrid imaging modality which combines high optical contrast and resolution in deep tissue imaging offers a novel, rapid and cost-effective way to analyze the morphological changes of venous sinus in comparison with the conventional imaging modalities. In this study, we examined the morphological changes of sagittal sinus in the rat brain due to intracranial pressure changes induced by Cerebrospinal fluid (CSF) extraction using low cost pulsed laser diode (PLD) based desktop (PAT) system. Our results indicate that the desktop PLD-PAT system can be employed to evaluate the changes in the cerebral venous sinus in preclinical models. We observed a ∼30% average increase in the area of sagittal venous sinus from the baseline, when the CSF is extracted.||URI:||https://hdl.handle.net/10356/146565||ISBN:||9781510632431||DOI:||10.1117/12.2543892||Rights:||Copyright 2020 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SCBE Conference Papers|
Updated on Aug 12, 2022
Updated on Aug 12, 2022
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