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Title: In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system
Authors: Rajendran, Praveenbalaji
Sahu, Samiran
Dienzo, Rhonnie Austria
Pramanik, Manojit
Keywords: Engineering::Bioengineering
Issue Date: 2020
Source: Rajendran, P., Sahu, S., Dienzo, R. A., & Pramanik, M. (2020). In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system. Proceedings of SPIE - Photons Plus Ultrasound: Imaging and Sensing 2020, 11240, 107-. doi:10.1117/12.2543892
Abstract: Assessment of morphological changes in cerebral venous sinus of small animal models is important to gain insights of various disease conditions such as intracranial hypotension, Idiopathic intracranial hypertension (IIH), Cerebral venous sinus thrombosis, subdural hematoma etc. Photoacoustic Tomography (PAT), a fast-growing non-invasive hybrid imaging modality which combines high optical contrast and resolution in deep tissue imaging offers a novel, rapid and cost-effective way to analyze the morphological changes of venous sinus in comparison with the conventional imaging modalities. In this study, we examined the morphological changes of sagittal sinus in the rat brain due to intracranial pressure changes induced by Cerebrospinal fluid (CSF) extraction using low cost pulsed laser diode (PLD) based desktop (PAT) system. Our results indicate that the desktop PLD-PAT system can be employed to evaluate the changes in the cerebral venous sinus in preclinical models. We observed a ∼30% average increase in the area of sagittal venous sinus from the baseline, when the CSF is extracted.
ISBN: 9781510632431
DOI: 10.1117/12.2543892
Rights: Copyright 2020 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Conference Papers

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