Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146643
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dc.contributor.authorRajendran, Praveenbalajien_US
dc.contributor.authorSahu, Samiranen_US
dc.contributor.authorDienzo, Rhonnie Austriaen_US
dc.contributor.authorPramanik, Manojiten_US
dc.date.accessioned2021-03-04T04:29:31Z-
dc.date.available2021-03-04T04:29:31Z-
dc.date.issued2020-
dc.identifier.citationRajendran, P., Sahu, S., Dienzo, R. A., & Pramanik, M. (2020). In vivo detection of venous sinus distension due to intracranial hypotension in small animal using pulsed-laser-diode photoacoustic tomography. Journal of Biophotonics, 13(6), e201960162-. doi:10.1002/jbio.201960162en_US
dc.identifier.issn1864-0648en_US
dc.identifier.other0000-0003-2865-5714-
dc.identifier.urihttps://hdl.handle.net/10356/146643-
dc.description.abstractIntracranial hypotension (IH) is a pathophysiological condition of reduced intracranial pressure caused by low cerebrospinal fluid (CSF) volume due to dural injuries from lumbar puncture, surgery, or trauma. Understanding the prognosis of IH in small animal models is important to gain insights on the complications associated with it such as orthostatic headache, cerebral venous thrombosis, coma, and so forth. Photoacoustic tomography (PAT) offers a novel and cost-effective way to perceive and detect IH in small animal models. In this study, a pulsed laser diode (PLD)-based PAT imaging system was used to examine the changes in the venous sinuses of the rat brain due to IH, induced through CSF extraction. After the CSF extraction, an increase in the sagittal sinus area by ~30% and width by 40% ± 5% was observed. These results provide supportive evidence that the PLD-PAT can be employed for detecting changes in sagittal sinus due to IH in rat model.en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Biophotonicsen_US
dc.rightsThis is the peer reviewed version of the following article: Rajendran, P., Sahu, S., Dienzo, R. A., & Pramanik, M. (2020). In vivo detection of venous sinus distension due to intracranial hypotension in small animal using pulsed-laser-diode photoacoustic tomography. Journal of Biophotonics, 13(6), e201960162-. doi:10.1002/jbio.201960162, which has been published in final form at https://doi.org/10.1002/jbio.201960162. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.subjectEngineering::Bioengineeringen_US
dc.titleIn vivo detection of venous sinus distension due to intracranial hypotension in small animal using pulsed-laser-diode photoacoustic tomographyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1002/jbio.201960162-
dc.description.versionAccepted versionen_US
dc.identifier.pmid32030895-
dc.identifier.scopus2-s2.0-85082079115-
dc.identifier.issue6en_US
dc.identifier.volume13en_US
dc.identifier.spagee201960162en_US
dc.subject.keywordsCerebrospinal Fluiden_US
dc.subject.keywordsIntracranial Hypotensionen_US
dc.description.acknowledgementThe study was funded by the Singapore Ministry of Health’s National Medical Research Council (NMRC) (NMRC/OFIRG/005/2016:M4062012). Dr. Samiran Sahu would like to thank the NTU-India Connect Research Internship Programme and IIT Kharagpur Foundation of the United States of America (USA) for providing the opportunity and assistantship to undertake the research internship program at Nanyang Technological University, Singapore.en_US
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