Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146643
Title: In vivo detection of venous sinus distension due to intracranial hypotension in small animal using pulsed-laser-diode photoacoustic tomography
Authors: Rajendran, Praveenbalaji
Sahu, Samiran
Dienzo, Rhonnie Austria
Pramanik, Manojit
Keywords: Engineering::Bioengineering
Issue Date: 2020
Source: Rajendran, P., Sahu, S., Dienzo, R. A., & Pramanik, M. (2020). In vivo detection of venous sinus distension due to intracranial hypotension in small animal using pulsed-laser-diode photoacoustic tomography. Journal of Biophotonics, 13(6), e201960162-. doi:10.1002/jbio.201960162
Journal: Journal of Biophotonics
Abstract: Intracranial hypotension (IH) is a pathophysiological condition of reduced intracranial pressure caused by low cerebrospinal fluid (CSF) volume due to dural injuries from lumbar puncture, surgery, or trauma. Understanding the prognosis of IH in small animal models is important to gain insights on the complications associated with it such as orthostatic headache, cerebral venous thrombosis, coma, and so forth. Photoacoustic tomography (PAT) offers a novel and cost-effective way to perceive and detect IH in small animal models. In this study, a pulsed laser diode (PLD)-based PAT imaging system was used to examine the changes in the venous sinuses of the rat brain due to IH, induced through CSF extraction. After the CSF extraction, an increase in the sagittal sinus area by ~30% and width by 40% ± 5% was observed. These results provide supportive evidence that the PLD-PAT can be employed for detecting changes in sagittal sinus due to IH in rat model.
URI: https://hdl.handle.net/10356/146643
ISSN: 1864-0648
DOI: 10.1002/jbio.201960162
Rights: This is the peer reviewed version of the following article: Rajendran, P., Sahu, S., Dienzo, R. A., & Pramanik, M. (2020). In vivo detection of venous sinus distension due to intracranial hypotension in small animal using pulsed-laser-diode photoacoustic tomography. Journal of Biophotonics, 13(6), e201960162-. doi:10.1002/jbio.201960162, which has been published in final form at https://doi.org/10.1002/jbio.201960162. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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