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dc.contributor.authorDee, Peifangen_US
dc.contributor.authorYou, Ha Youngen_US
dc.contributor.authorTeoh, Swee-Hinen_US
dc.contributor.authorLe Ferrand, Hortenseen_US
dc.identifier.citationDee, P., You, H. Y., Teoh, S.-H., & Le Ferrand, H. (2020). Bioinspired approaches to toughen calcium phosphate-based ceramics for bone repair. Journal of the Mechanical Behavior of Biomedical Materials, 112, 104078-. doi:10.1016/j.jmbbm.2020.104078en_US
dc.description.abstractTo respond to the increasing need for bone repair strategies, various types of biomaterials have been developed. Among those, calcium phosphate ceramics (CPCs) are promising since they possess a chemical composition similar to that of bones. To be suitable for implants, CPCs need to fulfill a number of biological and mechanical requirements. Fatigue resistance and toughness are two key mechanical properties that are still challenging to obtain in CPCs. This paper thus reviews and discusses current progress in the processing of CPCs with bioinspired microstructures for load-bearing applications. First, methods to obtain CPCs with bioinspired structure at individual lengthscales, namely nano-, micro-, and macroscale are discussed. Then, approaches to attain synergetic contribution of all lengthscales through a complex and biomimetic hierarchical structure are reviewed. The processing methods and their design capabilities are presented and the mechanical properties of the materials they can produce are analysed. Their limitations and challenges are finally discussed to suggest new directions for the fabrication of biomimetic bone implants with satisfactory properties. The paper could help biomedical researchers, materials scientists and engineers to join forces to create the next generation of bone implants.en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.relation.ispartofJournal of the Mechanical Behavior of Biomedical Materialsen_US
dc.rights© 2020 Elsevier Ltd. All rights reserved. This paper was published in Journal of the Mechanical Behavior of Biomedical Materials and is made available with permission of Elsevier Ltd.en_US
dc.titleBioinspired approaches to toughen calcium phosphate-based ceramics for bone repairen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.description.versionAccepted versionen_US
dc.subject.keywordsCalcium Phosphate Ceramicsen_US
dc.description.acknowledgementThe authors acknowledge financial support from the National Research Foundation, Singapore (Fellowship NRFF12-2020-0002).en_US
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