Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/146717
Title: Label-free high frame rate imaging of circulating blood clots using a dual modal ultrasound and photoacoustic system
Authors: Das, Dhiman
Sivasubramanian, Kathyayini
Rajendran, Praveenbalaji
Pramanik, Manojit
Keywords: Engineering::Bioengineering
Issue Date: 2021
Source: Das, D., Sivasubramanian, K., Rajendran, P., & Pramanik, M. (2021). Label-free high frame rate imaging of circulating blood clots using a dual modal ultrasound and photoacoustic system. Journal of Biophotonics, 14(3), 202000371-. doi:10.1002/jbio.202000371
Journal: Journal of Biophotonics
Abstract: Deep vein thrombosis (DVT) is a disorder when a blood clot (thrombus) is formed in one of the deep veins. These clots detach from the original sites and circulate in the blood stream at high velocities. Diagnosing these blood clots at an early stage is necessary to decide the treatment strategy. For label-free, in vivo and real-time detection, high framerate photoacoustic imaging can be used. In this work, a dual modal clinical ultrasound (US) and photoacoustic (PA) system is used for the high framerate PA imaging of circulating blood clots in blood at linear velocities up to 107 cm/sec. Blood clot had 1.4 times higher signal-to-noise ratio (SNR) in the static mode and 1.3 times higher SNR compared to blood PA signal in the flow experiments. This work demonstrates that fast-moving circulating blood clots are easy to recognize against the background PA signal and may aid in early diagnosis.
URI: https://hdl.handle.net/10356/146717
ISSN: 1864-0648
DOI: 10.1002/jbio.202000371
Rights: This is the peer reviewed version of the following article: Das, D., Sivasubramanian, K., Rajendran, P., & Pramanik, M. (2021). Label-free high frame rate imaging of circulating blood clots using a dual modal ultrasound and photoacoustic systeme. Journal of Biophotonics, 14(3), 202000371-. doi:10.1002/jbio.202000371, which has been published in final form at https://doi.org/10.1002/jbio.202000371. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: embargo_20220302
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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